Growth factor delivery from self-assembling nanofibers to facilitate islet transplantation

John C. Stendahl, Ling Jia Wang, Lesley W. Chow, Dixon B. Kaufman, Samuel I Stupp

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Recent advances in nanotechnology and molecular self-assembly may provide novel solutions to current cell transplantation deficiencies. Heparin-binding peptide amphiphiles (HBPAs) self-assemble from aqueous media into nanofibers that bind growth factors through interactions with the bioactive polymer heparin. In this report, we demonstrate that delivery of vascular endothelial growth factor and fibroblast growth factor-2 from HBPA scaffolds significantly increases blood vessel density in the mouse omentum over control scaffolds without growth factors (P

Original languageEnglish
Pages (from-to)478-481
Number of pages4
JournalTransplantation
Volume86
Issue number3
DOIs
Publication statusPublished - Aug 15 2008

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Keywords

  • Fibroblast growth factor-2
  • Islet transplantation
  • Omentum
  • Peptide amphiphile nanofibers
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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