H/D exchange at aromatic and heteroaromatic hydrocarbons using D 2O as the deuterium source and ruthenium dihydrogen complexes as the catalyst

Martin H.G. Prechtl, Markus Hölscher, Yehoshoa Ben-David, Nils Theyssen, Rebekka Loschen, David Milstein, Walter Leitner

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Getting heavy: At temperatures as low as 50°C, D2O can serve as a cheap and readily available deuterium source for the efficient deuteration of aromatic and heteroaromatic substrates if nonclassical ruthenium hydride complexes are used as catalysts (see scheme). DFT calculations support a catalytic cycle comprising σ-bond metathesis as the key step for the exchange processes. (Chemical Equation Presented).

Original languageEnglish
Pages (from-to)2269-2272
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number13
DOIs
Publication statusPublished - Jun 29 2007

Keywords

  • C-H activation
  • Density functional calculations
  • H/D exchange
  • Homogeneous catalysis
  • Ruthenium

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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