Getting heavy: At temperatures as low as 50°C, D2O can serve as a cheap and readily available deuterium source for the efficient deuteration of aromatic and heteroaromatic substrates if nonclassical ruthenium hydride complexes are used as catalysts (see scheme). DFT calculations support a catalytic cycle comprising σ-bond metathesis as the key step for the exchange processes. (Chemical Equation Presented).
- C-H activation
- Density functional calculations
- H/D exchange
- Homogeneous catalysis
ASJC Scopus subject areas