Heparin binding nanostructures to promote growth of blood vessels

Kanya Rajangam, Heather A. Behanna, Michael J. Hui, Xiaoqiang Han, James F. Hulvat, Jon W. Lomasney, Samuel I Stupp

Research output: Contribution to journalArticle

320 Citations (Scopus)

Abstract

Controlling new blood vessel formation is of interest in regenerative medicine and cancer treatment. Heparin, a biopolymer that binds to angiogenic growth factors, was used to nucleate the self-assembly of nanostructures from designed peptide amphiphile molecules. This process yields rigid nanofibers that display heparin chains to orient proteins for cell signaling. In vivo, the nanostructures stimulated extensive new blood vessel formation using nanogram amounts of growth-factor proteins that by themselves did not induce any detectable angiogenesis.

Original languageEnglish
Pages (from-to)2086-2090
Number of pages5
JournalNano Letters
Volume6
Issue number9
DOIs
Publication statusPublished - Sep 2006

Fingerprint

heparins
blood vessels
Blood vessels
Heparin
Nanostructures
Intercellular Signaling Peptides and Proteins
Cell signaling
proteins
Proteins
angiogenesis
Amphiphiles
Biopolymers
Oncology
biopolymers
Nanofibers
medicine
Self assembly
Peptides
peptides
self assembly

ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

Cite this

Rajangam, K., Behanna, H. A., Hui, M. J., Han, X., Hulvat, J. F., Lomasney, J. W., & Stupp, S. I. (2006). Heparin binding nanostructures to promote growth of blood vessels. Nano Letters, 6(9), 2086-2090. https://doi.org/10.1021/nl0613555

Heparin binding nanostructures to promote growth of blood vessels. / Rajangam, Kanya; Behanna, Heather A.; Hui, Michael J.; Han, Xiaoqiang; Hulvat, James F.; Lomasney, Jon W.; Stupp, Samuel I.

In: Nano Letters, Vol. 6, No. 9, 09.2006, p. 2086-2090.

Research output: Contribution to journalArticle

Rajangam, K, Behanna, HA, Hui, MJ, Han, X, Hulvat, JF, Lomasney, JW & Stupp, SI 2006, 'Heparin binding nanostructures to promote growth of blood vessels', Nano Letters, vol. 6, no. 9, pp. 2086-2090. https://doi.org/10.1021/nl0613555
Rajangam K, Behanna HA, Hui MJ, Han X, Hulvat JF, Lomasney JW et al. Heparin binding nanostructures to promote growth of blood vessels. Nano Letters. 2006 Sep;6(9):2086-2090. https://doi.org/10.1021/nl0613555
Rajangam, Kanya ; Behanna, Heather A. ; Hui, Michael J. ; Han, Xiaoqiang ; Hulvat, James F. ; Lomasney, Jon W. ; Stupp, Samuel I. / Heparin binding nanostructures to promote growth of blood vessels. In: Nano Letters. 2006 ; Vol. 6, No. 9. pp. 2086-2090.
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