Heparin binding nanostructures to promote growth of blood vessels

Kanya Rajangam, Heather A. Behanna, Michael J. Hui, Xiaoqiang Han, James F. Hulvat, Jon W. Lomasney, Samuel I. Stupp

Research output: Contribution to journalArticle

346 Citations (Scopus)

Abstract

Controlling new blood vessel formation is of interest in regenerative medicine and cancer treatment. Heparin, a biopolymer that binds to angiogenic growth factors, was used to nucleate the self-assembly of nanostructures from designed peptide amphiphile molecules. This process yields rigid nanofibers that display heparin chains to orient proteins for cell signaling. In vivo, the nanostructures stimulated extensive new blood vessel formation using nanogram amounts of growth-factor proteins that by themselves did not induce any detectable angiogenesis.

Original languageEnglish
Pages (from-to)2086-2090
Number of pages5
JournalNano letters
Volume6
Issue number9
DOIs
Publication statusPublished - Sep 1 2006

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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  • Cite this

    Rajangam, K., Behanna, H. A., Hui, M. J., Han, X., Hulvat, J. F., Lomasney, J. W., & Stupp, S. I. (2006). Heparin binding nanostructures to promote growth of blood vessels. Nano letters, 6(9), 2086-2090. https://doi.org/10.1021/nl0613555