Heterogeneously catalyzed selective hydrogenation of amides to alcohols and amines

Yinjun Xie, Peng Hu, Tatyana Bendikov, David Milstein

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report the heterogeneously catalyzed hydrogenation of amides to form alcohols and amines. This C-N bond cleavage reaction is catalyzed by silver on γ-alumina, proceeds smoothly in high yields and 100% selectivity, and is effective for both benzamides and aliphatic amides. This is in contrast to amide hydrogenation catalyzed by heterogeneous catalysts, which generally proceeds via C-O bond cleavage. Recycling experiments show that the catalyst Ag/γ-Al2O3 can be easily recovered and regenerated without decrease in catalytic activity.

Original languageEnglish
Pages (from-to)2784-2788
Number of pages5
JournalCatalysis Science and Technology
Volume8
Issue number11
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Amides
Hydrogenation
Amines
Alcohols
Benzamides
Catalysts
Aluminum Oxide
Chemical bonds
Silver
Recycling
Catalyst activity
Alumina
Carbon
Experiments

ASJC Scopus subject areas

  • Catalysis

Cite this

Heterogeneously catalyzed selective hydrogenation of amides to alcohols and amines. / Xie, Yinjun; Hu, Peng; Bendikov, Tatyana; Milstein, David.

In: Catalysis Science and Technology, Vol. 8, No. 11, 01.01.2018, p. 2784-2788.

Research output: Contribution to journalArticle

Xie, Yinjun ; Hu, Peng ; Bendikov, Tatyana ; Milstein, David. / Heterogeneously catalyzed selective hydrogenation of amides to alcohols and amines. In: Catalysis Science and Technology. 2018 ; Vol. 8, No. 11. pp. 2784-2788.
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