Abstract
We report the heterogeneously catalyzed hydrogenation of amides to form alcohols and amines. This C-N bond cleavage reaction is catalyzed by silver on γ-alumina, proceeds smoothly in high yields and 100% selectivity, and is effective for both benzamides and aliphatic amides. This is in contrast to amide hydrogenation catalyzed by heterogeneous catalysts, which generally proceeds via C-O bond cleavage. Recycling experiments show that the catalyst Ag/γ-Al2O3 can be easily recovered and regenerated without decrease in catalytic activity.
| Original language | English |
|---|---|
| Pages (from-to) | 2784-2788 |
| Number of pages | 5 |
| Journal | Catalysis Science and Technology |
| Volume | 8 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Jan 1 2018 |
ASJC Scopus subject areas
- Catalysis
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Cite this
Xie, Y., Hu, P., Bendikov, T., & Milstein, D. (2018). Heterogeneously catalyzed selective hydrogenation of amides to alcohols and amines. Catalysis Science and Technology, 8(11), 2784-2788. https://doi.org/10.1039/c8cy00112j