Abstract
The efficiency and dynamics of hole transport via base mismatches and strand crossings have been determined for 10 DNA hairpins by means of femtosecond transient absorption spectroscopy. The hairpins possess a stilbenedicarboxamide hole donor and stilbenediether hole acceptor separated by seven base pairs. Hole transport occurs via an intra- or interstrand A3G4 diblock purine sequence that contains either a single base pair mismatch or strand crossing. Pyrimidine-pyrimidine mismatches (TT or CC) effectively block intrastrand hole transport; whereas purine-purine mismatches (AA or GG) permit efficient interstrand hole transport. Purine-to-purine intrastrand hole transport between adjacent matched base pairs is also moderately efficient (AG>AA>GG). Based upon these results AA mismatches are being employed in the design of three-way junctions for incorporation in prototype charge splitting and charge combining devices.
| Original language | English |
|---|---|
| Journal | Journal of Photochemistry and Photobiology A: Chemistry |
| DOIs | |
| Publication status | Accepted/In press - Jan 29 2016 |
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Keywords
- Base-pair mismatch
- DNA
- Donor-acceptor systems
- Hole transport
- Transient absorption spectroscopy
ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
- Physics and Astronomy(all)
Cite this
Hole transport in DNA hairpins via base mismatches and strand crossings : Efficiency and dynamics. / Thazhathveetil, Arun K.; Harris, Michelle A.; Young, Ryan M.; Wasielewski, Michael R; Lewis, Frederick D.
In: Journal of Photochemistry and Photobiology A: Chemistry, 29.01.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hole transport in DNA hairpins via base mismatches and strand crossings
T2 - Efficiency and dynamics
AU - Thazhathveetil, Arun K.
AU - Harris, Michelle A.
AU - Young, Ryan M.
AU - Wasielewski, Michael R
AU - Lewis, Frederick D.
PY - 2016/1/29
Y1 - 2016/1/29
N2 - The efficiency and dynamics of hole transport via base mismatches and strand crossings have been determined for 10 DNA hairpins by means of femtosecond transient absorption spectroscopy. The hairpins possess a stilbenedicarboxamide hole donor and stilbenediether hole acceptor separated by seven base pairs. Hole transport occurs via an intra- or interstrand A3G4 diblock purine sequence that contains either a single base pair mismatch or strand crossing. Pyrimidine-pyrimidine mismatches (TT or CC) effectively block intrastrand hole transport; whereas purine-purine mismatches (AA or GG) permit efficient interstrand hole transport. Purine-to-purine intrastrand hole transport between adjacent matched base pairs is also moderately efficient (AG>AA>GG). Based upon these results AA mismatches are being employed in the design of three-way junctions for incorporation in prototype charge splitting and charge combining devices.
AB - The efficiency and dynamics of hole transport via base mismatches and strand crossings have been determined for 10 DNA hairpins by means of femtosecond transient absorption spectroscopy. The hairpins possess a stilbenedicarboxamide hole donor and stilbenediether hole acceptor separated by seven base pairs. Hole transport occurs via an intra- or interstrand A3G4 diblock purine sequence that contains either a single base pair mismatch or strand crossing. Pyrimidine-pyrimidine mismatches (TT or CC) effectively block intrastrand hole transport; whereas purine-purine mismatches (AA or GG) permit efficient interstrand hole transport. Purine-to-purine intrastrand hole transport between adjacent matched base pairs is also moderately efficient (AG>AA>GG). Based upon these results AA mismatches are being employed in the design of three-way junctions for incorporation in prototype charge splitting and charge combining devices.
KW - Base-pair mismatch
KW - DNA
KW - Donor-acceptor systems
KW - Hole transport
KW - Transient absorption spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=84977151300&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84977151300&partnerID=8YFLogxK
U2 - 10.1016/j.jphotochem.2016.03.002
DO - 10.1016/j.jphotochem.2016.03.002
M3 - Article
AN - SCOPUS:84977151300
JO - Journal of Photochemistry and Photobiology A: Chemistry
JF - Journal of Photochemistry and Photobiology A: Chemistry
SN - 1010-6030
ER -