Identification and Optimization of Carbon Radicals on Hydrated Graphene Oxide for Ubiquitous Antibacterial Coatings

Ruibin Li, Nikhita D. Mansukhani, Linda M. Guiney, Zhaoxia Ji, Yichao Zhao, Chong Hyun Chang, Christopher T. French, Jeff F. Miller, Mark C Hersam, Andre E. Nel, Tian Xia

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

While the antibacterial properties of graphene oxide (GO) have been demonstrated across a spectrum of bacteria, the critical role of functional groups is unclear. To address this important issue, we utilized reduction and hydration methods to establish a GO library with different oxidation, hydroxyl, and carbon radical (•C) levels that can be used to study the impact on antibacterial activity. Using antibiotic-resistant bacteria as a test platform, we found that the •C density is most proximately associated with bacterial killing. Accordingly, hydrated GO (hGO), with the highest •C density, had the strongest antibacterial effects through membrane binding and induction of lipid peroxidation. To explore its potential applications, we demonstrated that coating of catheter and glass surfaces with hGO is capable of killing drug-resistant bacteria. In summary, •C is the principle surface moiety that can be utilized for clinical applications of GO-based antibacterial coatings.

Original languageEnglish
Pages (from-to)10966-10980
Number of pages15
JournalACS Nano
Volume10
Issue number12
DOIs
Publication statusPublished - Dec 27 2016

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Graphite
Oxides
Graphene
graphene
Carbon
bacteria
coatings
Coatings
Bacteria
optimization
oxides
carbon
antibiotics
Catheters
hydroxyl radicals
Antibiotics
Hydration
Hydroxyl Radical
Lipids
Functional groups

Keywords

  • antibacterial coating
  • antibiotic resistance
  • functionalization
  • graphene oxide
  • super bugs

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Li, R., Mansukhani, N. D., Guiney, L. M., Ji, Z., Zhao, Y., Chang, C. H., ... Xia, T. (2016). Identification and Optimization of Carbon Radicals on Hydrated Graphene Oxide for Ubiquitous Antibacterial Coatings. ACS Nano, 10(12), 10966-10980. https://doi.org/10.1021/acsnano.6b05692

Identification and Optimization of Carbon Radicals on Hydrated Graphene Oxide for Ubiquitous Antibacterial Coatings. / Li, Ruibin; Mansukhani, Nikhita D.; Guiney, Linda M.; Ji, Zhaoxia; Zhao, Yichao; Chang, Chong Hyun; French, Christopher T.; Miller, Jeff F.; Hersam, Mark C; Nel, Andre E.; Xia, Tian.

In: ACS Nano, Vol. 10, No. 12, 27.12.2016, p. 10966-10980.

Research output: Contribution to journalArticle

Li, R, Mansukhani, ND, Guiney, LM, Ji, Z, Zhao, Y, Chang, CH, French, CT, Miller, JF, Hersam, MC, Nel, AE & Xia, T 2016, 'Identification and Optimization of Carbon Radicals on Hydrated Graphene Oxide for Ubiquitous Antibacterial Coatings', ACS Nano, vol. 10, no. 12, pp. 10966-10980. https://doi.org/10.1021/acsnano.6b05692
Li, Ruibin ; Mansukhani, Nikhita D. ; Guiney, Linda M. ; Ji, Zhaoxia ; Zhao, Yichao ; Chang, Chong Hyun ; French, Christopher T. ; Miller, Jeff F. ; Hersam, Mark C ; Nel, Andre E. ; Xia, Tian. / Identification and Optimization of Carbon Radicals on Hydrated Graphene Oxide for Ubiquitous Antibacterial Coatings. In: ACS Nano. 2016 ; Vol. 10, No. 12. pp. 10966-10980.
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