Imidazole synthesis by transition metal free, base-mediated deaminative coupling of benzylamines and nitriles

Uttam Kumar Das, Linda J.W. Shimon, David Milstein

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A transition metal free, straightforward synthetic method for the preparation of substituted imidazoles is reported herein. Base promoted, deaminative coupling of benzylamines with nitriles results in the one-step synthesis of 2,4,5-trisubstituted imidazoles with liberation of ammonia. This protocol provides a practical strategy for the synthesis of valuable imidazole derivatives from readily available starting materials.

Original languageEnglish
Pages (from-to)13133-13136
Number of pages4
JournalChemical Communications
Volume53
Issue number98
DOIs
Publication statusPublished - Jan 1 2017

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Benzylamines
Imidazoles
Nitriles
Transition metals
Ammonia
Derivatives
imidazole

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Imidazole synthesis by transition metal free, base-mediated deaminative coupling of benzylamines and nitriles. / Das, Uttam Kumar; Shimon, Linda J.W.; Milstein, David.

In: Chemical Communications, Vol. 53, No. 98, 01.01.2017, p. 13133-13136.

Research output: Contribution to journalArticle

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