Increasing the speed limit for hole transport in DNA

Arun K. Thazhathveetil, Anton Trifonov, Michael R Wasielewski, Frederick D. Lewis

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Transport of positive charge or holes in DNA occurs via a thermally activated multi-step hopping mechanism. The fastest hopping rates reported to date are those for repeating poly(purine) sequences in which hopping occurs via a random walk mechanism with rate constants of k hop = 4.3 ×10 9 s -1 for poly(dG) and 1.2 ×10 9 s -1 for poly(dA). We report here the dynamics of charge separation in DNA conjugates possessing repeating 7-deazaadenine (dzA) sequences. These data provide an estimated value of k hop = 4.2 ×10 10 s -1 for poly(dzA), an order of magnitude faster than for poly(dG).

Original languageEnglish
Pages (from-to)11485-11487
Number of pages3
JournalJournal of the American Chemical Society
Volume133
Issue number30
DOIs
Publication statusPublished - Aug 3 2011

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Humulus
DNA
Rate constants
poly(dG)
7-deazaadenine
poly(dA)
purine

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Increasing the speed limit for hole transport in DNA. / Thazhathveetil, Arun K.; Trifonov, Anton; Wasielewski, Michael R; Lewis, Frederick D.

In: Journal of the American Chemical Society, Vol. 133, No. 30, 03.08.2011, p. 11485-11487.

Research output: Contribution to journalArticle

Thazhathveetil, Arun K. ; Trifonov, Anton ; Wasielewski, Michael R ; Lewis, Frederick D. / Increasing the speed limit for hole transport in DNA. In: Journal of the American Chemical Society. 2011 ; Vol. 133, No. 30. pp. 11485-11487.
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