Influence of aggregation on redox potentials of amphiphilic Cu(II) complexes modeled after bleomycin antibiotics

Giovanna Ghirlanda, Paolo Scrimin, Luis A. Echegoyen

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The influence of micellization on the redox potential of a series of three amphiphilic Cu(II) complexes was investigated by comparing their electrochemical properties on glassy carbon (GC) with those observed for the corresponding nonsurfactant models. The ligands examined were modeled after the metal-binding site of the antibiotic bleomycin (BLM). Comparison with the BLM-Cu(II) complex showed similar electrochemical behavior for the nonsurfactant complexes. The E1/2 values were assessed by cyclic voltammetry and Osteryoung square wave voltammetry and found to correlate with the structure of the complexes. The amphiphilic Cu(II) complexes displayed a significant positive shift (in the range 100-120 mV) with respect to their nonsurfactant models. Investigation of the electrochemistry of the copper complexes of both surfactant and nonsurfactant complexes in the presence of neutral (Triton-100), cationic (CTABr), and anionic (SDS) cosurfactants at concentrations below and above their cmc allowed us to differentiate between the electrostatic and hydrophobic contributions to the shift of the redox potentials.

Original languageEnglish
Pages (from-to)5188-5194
Number of pages7
JournalLangmuir
Volume12
Issue number21
Publication statusPublished - Oct 16 1996

Fingerprint

antibiotics
Bleomycin
Antibiotics
Agglomeration
Anti-Bacterial Agents
Micellization
shift
square waves
glassy carbon
Glassy carbon
Electrochemistry
Binding sites
Voltammetry
electrochemistry
Electrochemical properties
Surface-Active Agents
Cyclic voltammetry
Copper
Electrostatics
Surface active agents

ASJC Scopus subject areas

  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry

Cite this

Influence of aggregation on redox potentials of amphiphilic Cu(II) complexes modeled after bleomycin antibiotics. / Ghirlanda, Giovanna; Scrimin, Paolo; Echegoyen, Luis A.

In: Langmuir, Vol. 12, No. 21, 16.10.1996, p. 5188-5194.

Research output: Contribution to journalArticle

@article{6c8eec8ed45a432c9a8cf0986230155a,
title = "Influence of aggregation on redox potentials of amphiphilic Cu(II) complexes modeled after bleomycin antibiotics",
abstract = "The influence of micellization on the redox potential of a series of three amphiphilic Cu(II) complexes was investigated by comparing their electrochemical properties on glassy carbon (GC) with those observed for the corresponding nonsurfactant models. The ligands examined were modeled after the metal-binding site of the antibiotic bleomycin (BLM). Comparison with the BLM-Cu(II) complex showed similar electrochemical behavior for the nonsurfactant complexes. The E1/2 values were assessed by cyclic voltammetry and Osteryoung square wave voltammetry and found to correlate with the structure of the complexes. The amphiphilic Cu(II) complexes displayed a significant positive shift (in the range 100-120 mV) with respect to their nonsurfactant models. Investigation of the electrochemistry of the copper complexes of both surfactant and nonsurfactant complexes in the presence of neutral (Triton-100), cationic (CTABr), and anionic (SDS) cosurfactants at concentrations below and above their cmc allowed us to differentiate between the electrostatic and hydrophobic contributions to the shift of the redox potentials.",
author = "Giovanna Ghirlanda and Paolo Scrimin and Echegoyen, {Luis A.}",
year = "1996",
month = "10",
day = "16",
language = "English",
volume = "12",
pages = "5188--5194",
journal = "Langmuir",
issn = "0743-7463",
publisher = "American Chemical Society",
number = "21",

}

TY - JOUR

T1 - Influence of aggregation on redox potentials of amphiphilic Cu(II) complexes modeled after bleomycin antibiotics

AU - Ghirlanda, Giovanna

AU - Scrimin, Paolo

AU - Echegoyen, Luis A.

PY - 1996/10/16

Y1 - 1996/10/16

N2 - The influence of micellization on the redox potential of a series of three amphiphilic Cu(II) complexes was investigated by comparing their electrochemical properties on glassy carbon (GC) with those observed for the corresponding nonsurfactant models. The ligands examined were modeled after the metal-binding site of the antibiotic bleomycin (BLM). Comparison with the BLM-Cu(II) complex showed similar electrochemical behavior for the nonsurfactant complexes. The E1/2 values were assessed by cyclic voltammetry and Osteryoung square wave voltammetry and found to correlate with the structure of the complexes. The amphiphilic Cu(II) complexes displayed a significant positive shift (in the range 100-120 mV) with respect to their nonsurfactant models. Investigation of the electrochemistry of the copper complexes of both surfactant and nonsurfactant complexes in the presence of neutral (Triton-100), cationic (CTABr), and anionic (SDS) cosurfactants at concentrations below and above their cmc allowed us to differentiate between the electrostatic and hydrophobic contributions to the shift of the redox potentials.

AB - The influence of micellization on the redox potential of a series of three amphiphilic Cu(II) complexes was investigated by comparing their electrochemical properties on glassy carbon (GC) with those observed for the corresponding nonsurfactant models. The ligands examined were modeled after the metal-binding site of the antibiotic bleomycin (BLM). Comparison with the BLM-Cu(II) complex showed similar electrochemical behavior for the nonsurfactant complexes. The E1/2 values were assessed by cyclic voltammetry and Osteryoung square wave voltammetry and found to correlate with the structure of the complexes. The amphiphilic Cu(II) complexes displayed a significant positive shift (in the range 100-120 mV) with respect to their nonsurfactant models. Investigation of the electrochemistry of the copper complexes of both surfactant and nonsurfactant complexes in the presence of neutral (Triton-100), cationic (CTABr), and anionic (SDS) cosurfactants at concentrations below and above their cmc allowed us to differentiate between the electrostatic and hydrophobic contributions to the shift of the redox potentials.

UR - http://www.scopus.com/inward/record.url?scp=0001540652&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0001540652&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0001540652

VL - 12

SP - 5188

EP - 5194

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 21

ER -