Inspiration from nature for heterogeneous catalysis

Harold H Kung, Mayfair C. Kung

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

The desire to attain high activity and selectivity achieved by systems in Nature has long been a source of inspiration for research in heterogeneous catalysis, and significant progress has been made. A summary is presented here of the progress in applying concepts in enzymes and cellular systems to develop artificial systems. The discussion is organized according to the length scale: dimensions of small molecules (∼1 nm), protein (nm-μm), and cells (∼ μm). At the smallest dimension, the focus is on the active site, and effects observed include functional group cooperation, substrate partitioning, site isolation, transition state stabilization, and pK shifts. At the intermediate dimension of a protein, effects observed include size exclusion, steric constraint, and docking and induced fit. Interestingly, the oscillation phenomenon observed in artificial systems, which is due to collective behavior of atoms, is not observed in natural systems. At the largest, cellular scale, processes of interest include cascade reaction and tandem reactions, and metabolon is one natural system to emulate. There are interesting but nascent developments to emulate phenomena such as self-healing, stimuli-responsiveness, reaction coupling, and designed hierarchical distribution of pores and channels across all scales. Much could be gained if catalysts can be designed to incorporate these properties.

Original languageEnglish
Pages (from-to)1643-1652
Number of pages10
JournalCatalysis Letters
Volume144
Issue number10
DOIs
Publication statusPublished - Jan 1 2014

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Catalysis
Proteins
Functional groups
Enzymes
Stabilization
Atoms
Catalysts
Molecules
Substrates

Keywords

  • Bio-inspired
  • Heterogeneous catalysis
  • Nature-inspired

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Inspiration from nature for heterogeneous catalysis. / Kung, Harold H; Kung, Mayfair C.

In: Catalysis Letters, Vol. 144, No. 10, 01.01.2014, p. 1643-1652.

Research output: Contribution to journalReview article

Kung, Harold H ; Kung, Mayfair C. / Inspiration from nature for heterogeneous catalysis. In: Catalysis Letters. 2014 ; Vol. 144, No. 10. pp. 1643-1652.
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