Interactions between segmented polyurethane surfaces and the plasma protein fibrinogen

Samuel I Stupp, J. W. Kauffman, S. H. Carr

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Surfaces of a segmented polyurethane were varied by casting on poly(ethylene terephthalate) (PET) and glass substrates, and were characterized through infrared-attenuated total-reflection spectroscopy (ATR). Surfaces cast on glass substrates showed a higher content of polyether segments, whereas those cast on PET contained a higher relative concentration of aromatic segments. Adsorption, and possible conformational changes of fibrinogen, were found to be more substantial on polymer surfaces having a higher content of polyether segments. It is concluded that the relatively good blood compatibility of segmented polyurethanes is partly due to the presence of peptide-like bonds on aromatic segments.

Original languageEnglish
Pages (from-to)237-250
Number of pages14
JournalJournal of Biomedical Materials Research
Volume11
Issue number2
Publication statusPublished - Mar 1977

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

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