Interconnecting gold islands with DNA origami nanotubes

Baoquan Ding, Hao Wu, Wei Xu, Zhao Zhao, Yan Liu, Hongbin Yu, Hao Yan

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Scaffolded DNA origami has recently emerged as a versatile, programmable method to fold DNA into arbitrarily shaped nanostructures that are spatially addressable, with sub-10-nm resolution. Toward functional DNA nanotechnology, one of the key challenges is to integrate the bottom-up self-assembly of DNA origami with the top-down lithographic methods used to generate surface patterning. In this report we demonstrate that fixed length DNA origami nanotubes, modified with multiple thiol groups near both ends, can be used to connect surface patterned gold islands (tens of nanometers in diameter) fabricated by electron beam lithography (EBL). Atomic force microscopic imaging verified that the DNA origami nanotubes can be efficiently aligned between gold islands with various interisland distances and relative locations. This development represents progress toward the goal of bridging bottom-up and top-down assembly approaches.

Original languageEnglish
Pages (from-to)5065-5069
Number of pages5
JournalNano Letters
Volume10
Issue number12
DOIs
Publication statusPublished - Dec 8 2010

Fingerprint

Gold
Nanotubes
nanotubes
DNA
deoxyribonucleic acid
gold
Electron beam lithography
nanotechnology
Nanotechnology
Sulfhydryl Compounds
thiols
Self assembly
self assembly
Nanostructures
lithography
assembly
electron beams
Imaging techniques

Keywords

  • bottom-up
  • DNA origami
  • self-assembly
  • structural DNA nanotechnology
  • top-down

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

Cite this

Interconnecting gold islands with DNA origami nanotubes. / Ding, Baoquan; Wu, Hao; Xu, Wei; Zhao, Zhao; Liu, Yan; Yu, Hongbin; Yan, Hao.

In: Nano Letters, Vol. 10, No. 12, 08.12.2010, p. 5065-5069.

Research output: Contribution to journalArticle

Ding, B, Wu, H, Xu, W, Zhao, Z, Liu, Y, Yu, H & Yan, H 2010, 'Interconnecting gold islands with DNA origami nanotubes', Nano Letters, vol. 10, no. 12, pp. 5065-5069. https://doi.org/10.1021/nl1033073
Ding B, Wu H, Xu W, Zhao Z, Liu Y, Yu H et al. Interconnecting gold islands with DNA origami nanotubes. Nano Letters. 2010 Dec 8;10(12):5065-5069. https://doi.org/10.1021/nl1033073
Ding, Baoquan ; Wu, Hao ; Xu, Wei ; Zhao, Zhao ; Liu, Yan ; Yu, Hongbin ; Yan, Hao. / Interconnecting gold islands with DNA origami nanotubes. In: Nano Letters. 2010 ; Vol. 10, No. 12. pp. 5065-5069.
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