Ir-catalyzed functionalization of C-H bonds

Jongwook Choi, Alan S Goldman

Research output: Chapter in Book/Report/Conference proceedingChapter

40 Citations (Scopus)

Abstract

The ability to selectively functionalize C-H bonds holds enormous potential value in virtually every sphere of organic chemistry, from fuels to pharmaceuticals. Transition metal complexes have shown great promise in this context. Iridium provided the first examples of oxidative addition of C-H bonds; this addition is key to iridium's leading role in alkane dehydrogenation and related reactions. Catalysts based on iridium have also proven highly effective for valuable borylations of C-H bonds and, to a lesser extent, for C-Si coupling. Compared with other platinum group metals, iridium chemistry has not been developed as extensively for the elaboration of C-C bonds from C-H bonds, but significant promise is indicated, particularly for coupling with simple hydrocarbons which lack functionalities that can act as directing groups.

Original languageEnglish
Title of host publicationTopics in Organometallic Chemistry
Pages139-167
Number of pages29
Volume34
DOIs
Publication statusPublished - 2011

Publication series

NameTopics in Organometallic Chemistry
Volume34
ISSN (Print)14366002

Fingerprint

Iridium
Alkanes
Coordination Complexes
Dehydrogenation
Metal complexes
Hydrocarbons
Platinum
Drug products
Paraffins
Transition metals
Metals
Catalysts
Pharmaceutical Preparations

Keywords

  • Alkane metathesis
  • Borylation
  • C-H bond activation
  • Dehydrogenation
  • Hydroarylation
  • Iridium catalyst
  • Silylation

ASJC Scopus subject areas

  • Organic Chemistry
  • Inorganic Chemistry
  • Catalysis

Cite this

Choi, J., & Goldman, A. S. (2011). Ir-catalyzed functionalization of C-H bonds. In Topics in Organometallic Chemistry (Vol. 34, pp. 139-167). (Topics in Organometallic Chemistry; Vol. 34). https://doi.org/10.1007/978-3-642-15334-1_6

Ir-catalyzed functionalization of C-H bonds. / Choi, Jongwook; Goldman, Alan S.

Topics in Organometallic Chemistry. Vol. 34 2011. p. 139-167 (Topics in Organometallic Chemistry; Vol. 34).

Research output: Chapter in Book/Report/Conference proceedingChapter

Choi, J & Goldman, AS 2011, Ir-catalyzed functionalization of C-H bonds. in Topics in Organometallic Chemistry. vol. 34, Topics in Organometallic Chemistry, vol. 34, pp. 139-167. https://doi.org/10.1007/978-3-642-15334-1_6
Choi J, Goldman AS. Ir-catalyzed functionalization of C-H bonds. In Topics in Organometallic Chemistry. Vol. 34. 2011. p. 139-167. (Topics in Organometallic Chemistry). https://doi.org/10.1007/978-3-642-15334-1_6
Choi, Jongwook ; Goldman, Alan S. / Ir-catalyzed functionalization of C-H bonds. Topics in Organometallic Chemistry. Vol. 34 2011. pp. 139-167 (Topics in Organometallic Chemistry).
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