Iron-Catalyzed Mild and Selective Hydrogenative Cross-Coupling of Nitriles and Amines To Form Secondary Aldimines

Subrata Chakraborty; Gregory Leitus; David Milstein

doi:10.1002/anie.201608537

Iron-Catalyzed Mild and Selective Hydrogenative Cross-Coupling of Nitriles and Amines To Form Secondary Aldimines

Subrata Chakraborty, Gregory Leitus, David Milstein

Weizmann Institute of Science, Israel

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

The first example of a base-metal-catalyzed homogeneous hydrogenative coupling of nitriles and amines to selectively form secondary cross-imines is reported. The reaction is catalyzed under mild conditions by a well-defined (iPr-PNP)Fe(H)Br(CO) pincer pre-catalyst and catalytic tBuOK.

Original language	English
Pages (from-to)	2074-2078
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	56
Issue number	8
DOIs	https://doi.org/10.1002/anie.201608537
Publication status	Published - Feb 13 2017

Keywords

cross-coupling
hydrogenation
imines
iron
nitriles

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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