Iron-Catalyzed Mild and Selective Hydrogenative Cross-Coupling of Nitriles and Amines To Form Secondary Aldimines

Subrata Chakraborty, Gregory Leitus, David Milstein

Research output: Contribution to journal › Article

28 Citations (Scopus)

Abstract

The first example of a base-metal-catalyzed homogeneous hydrogenative coupling of nitriles and amines to selectively form secondary cross-imines is reported. The reaction is catalyzed under mild conditions by a well-defined (iPr-PNP)Fe(H)Br(CO) pincer pre-catalyst and catalytic tBuOK.

Original languageEnglish
Pages (from-to)2074-2078
Number of pages5
JournalAngewandte Chemie - International Edition
Volume56
Issue number8
DOIs
Publication statusPublished - 2017

Fingerprint

Nitriles
Imines
Carbon Monoxide
Amines
Iron
Metals
Catalysts

Keywords

  • cross-coupling
  • hydrogenation
  • imines
  • iron
  • nitriles

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Iron-Catalyzed Mild and Selective Hydrogenative Cross-Coupling of Nitriles and Amines To Form Secondary Aldimines. / Chakraborty, Subrata; Leitus, Gregory; Milstein, David.

In: Angewandte Chemie - International Edition, Vol. 56, No. 8, 2017, p. 2074-2078.

Research output: Contribution to journal › Article

Chakraborty, S, Leitus, G & Milstein, D 2017, 'Iron-Catalyzed Mild and Selective Hydrogenative Cross-Coupling of Nitriles and Amines To Form Secondary Aldimines', Angewandte Chemie - International Edition, vol. 56, no. 8, pp. 2074-2078. https://doi.org/10.1002/anie.201608537
Chakraborty S, Leitus G, Milstein D. Iron-Catalyzed Mild and Selective Hydrogenative Cross-Coupling of Nitriles and Amines To Form Secondary Aldimines. Angewandte Chemie - International Edition. 2017;56(8):2074-2078. https://doi.org/10.1002/anie.201608537
Chakraborty, Subrata ; Leitus, Gregory ; Milstein, David. / Iron-Catalyzed Mild and Selective Hydrogenative Cross-Coupling of Nitriles and Amines To Form Secondary Aldimines. In: Angewandte Chemie - International Edition. 2017 ; Vol. 56, No. 8. pp. 2074-2078.
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