Iron-Catalyzed Mild and Selective Hydrogenative Cross-Coupling of Nitriles and Amines To Form Secondary Aldimines

Subrata Chakraborty, Gregory Leitus, David Milstein

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39 Citations (Scopus)

Abstract

The first example of a base-metal-catalyzed homogeneous hydrogenative coupling of nitriles and amines to selectively form secondary cross-imines is reported. The reaction is catalyzed under mild conditions by a well-defined (iPr-PNP)Fe(H)Br(CO) pincer pre-catalyst and catalytic tBuOK.

Original languageEnglish
Pages (from-to)2074-2078
Number of pages5
JournalAngewandte Chemie - International Edition
Volume56
Issue number8
DOIs
Publication statusPublished - 2017

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Keywords

  • cross-coupling
  • hydrogenation
  • imines
  • iron
  • nitriles

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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