Abstract
The first example of a base-metal-catalyzed homogeneous hydrogenative coupling of nitriles and amines to selectively form secondary cross-imines is reported. The reaction is catalyzed under mild conditions by a well-defined (iPr-PNP)Fe(H)Br(CO) pincer pre-catalyst and catalytic tBuOK.
| Original language | English |
|---|---|
| Pages (from-to) | 2074-2078 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 56 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2017 |
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Keywords
- cross-coupling
- hydrogenation
- imines
- iron
- nitriles
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
Cite this
Iron-Catalyzed Mild and Selective Hydrogenative Cross-Coupling of Nitriles and Amines To Form Secondary Aldimines. / Chakraborty, Subrata; Leitus, Gregory; Milstein, David.
In: Angewandte Chemie - International Edition, Vol. 56, No. 8, 2017, p. 2074-2078.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Iron-Catalyzed Mild and Selective Hydrogenative Cross-Coupling of Nitriles and Amines To Form Secondary Aldimines
AU - Chakraborty, Subrata
AU - Leitus, Gregory
AU - Milstein, David
PY - 2017
Y1 - 2017
N2 - The first example of a base-metal-catalyzed homogeneous hydrogenative coupling of nitriles and amines to selectively form secondary cross-imines is reported. The reaction is catalyzed under mild conditions by a well-defined (iPr-PNP)Fe(H)Br(CO) pincer pre-catalyst and catalytic tBuOK.
AB - The first example of a base-metal-catalyzed homogeneous hydrogenative coupling of nitriles and amines to selectively form secondary cross-imines is reported. The reaction is catalyzed under mild conditions by a well-defined (iPr-PNP)Fe(H)Br(CO) pincer pre-catalyst and catalytic tBuOK.
KW - cross-coupling
KW - hydrogenation
KW - imines
KW - iron
KW - nitriles
UR - http://www.scopus.com/inward/record.url?scp=85011901187&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85011901187&partnerID=8YFLogxK
U2 - 10.1002/anie.201608537
DO - 10.1002/anie.201608537
M3 - Article
C2 - 28078777
AN - SCOPUS:85011901187
VL - 56
SP - 2074
EP - 2078
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 8
ER -