Irreversible blocking of ion channels using functionalized single-walled carbon nanotubes

Manish Chhowalla, H. Emrah Unalan, Yubing Wang, Zafar Iqbal, Kiho Park, Federico Sesti

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We demonstrate irreversible blocking of ion channels using single-wall carbon nanotubes (SWNTs) functionalized with 2-aminoethylmethane thiosulfonate (MTSET). In contrast, as-produced and purified SWNTs exhibit reversible blocking, indicating that the MTSET molecule attached to SWNTs chemically interacts with the cysteine groups in the ion channels. Functionalization of SWNTs with MTSET is inferred from Fourier transform infrared (FTIR) spectroscopy, which clearly shows absorptions due to -CH stretching and deformation modes, and decrease in intensity of the -COOH line due to reaction of acid functionalized SWNTs with the basic N-CH3 end of the MTSET molecule.

Original languageEnglish
Pages (from-to)2982-2986
Number of pages5
JournalNanotechnology
Volume16
Issue number12
DOIs
Publication statusPublished - Dec 1 2005

Fingerprint

Carbon Nanotubes
Single-walled carbon nanotubes (SWCN)
Ion Channels
Carbon nanotubes
carbon nanotubes
Ions
Molecules
cysteine
Stretching
Fourier transform infrared spectroscopy
Cysteine
molecules
infrared spectroscopy
methylidyne
acids
Acids

ASJC Scopus subject areas

  • Engineering (miscellaneous)
  • Materials Science(all)
  • Physics and Astronomy (miscellaneous)

Cite this

Irreversible blocking of ion channels using functionalized single-walled carbon nanotubes. / Chhowalla, Manish; Unalan, H. Emrah; Wang, Yubing; Iqbal, Zafar; Park, Kiho; Sesti, Federico.

In: Nanotechnology, Vol. 16, No. 12, 01.12.2005, p. 2982-2986.

Research output: Contribution to journalArticle

Chhowalla, Manish ; Unalan, H. Emrah ; Wang, Yubing ; Iqbal, Zafar ; Park, Kiho ; Sesti, Federico. / Irreversible blocking of ion channels using functionalized single-walled carbon nanotubes. In: Nanotechnology. 2005 ; Vol. 16, No. 12. pp. 2982-2986.
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