Light-Responsive Dynamic DNA-Origami-Based Plasmonic Assemblies

Joonas Ryssy, Ashwin K. Natarajan, Jinhua Wang, Arttu J. Lehtonen, Minh Kha Nguyen, Rafal Klajn, Anton Kuzyk

Research output: Contribution to journalArticlepeer-review

Abstract

DNA nanotechnology offers a versatile toolbox for precise spatial and temporal manipulation of matter on the nanoscale. However, rendering DNA-based systems responsive to light has remained challenging. Herein, we describe the remote manipulation of native (non-photoresponsive) chiral plasmonic molecules (CPMs) using light. Our strategy is based on the use of a photoresponsive medium comprising a merocyanine-based photoacid. Upon exposure to visible light, the medium decreases its pH, inducing the formation of DNA triplex links, leading to a spatial reconfiguration of the CPMs. The process can be reversed simply by turning the light off and it can be repeated for multiple cycles. The degree of the overall chirality change in an ensemble of CPMs depends on the CPM fraction undergoing reconfiguration, which, remarkably, depends on and can be tuned by the intensity of incident light. Such a dynamic, remotely controlled system could aid in further advancing DNA-based devices and nanomaterials.

Original languageEnglish
Pages (from-to)5859-5863
Number of pages5
JournalAngewandte Chemie - International Edition
Volume60
Issue number11
DOIs
Publication statusPublished - Mar 8 2021

Keywords

  • chiral plasmonics
  • DNA origami
  • photoacid
  • self-assembly
  • stimuli-responsive materials

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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