Light-triggered bioactivity in three dimensions

Takahiro Muraoka, Chung Yan Koh, Honggang Cui, Samuel I. Stupp

Research output: Contribution to journalArticlepeer-review

155 Citations (Scopus)

Abstract

Photocleavage of a 2-nitrobenzyl group in a bioactive peptide amphiphile containing the Arg-Gly-Asp (RGD) epitope triggers a sol-to-gel transition as nanospheres are converted to nanofibers (see picture). This morphological change enhances the bioactivity of the nanostructures surrounding cells in three dimensions.

Original languageEnglish
Pages (from-to)5946-5949
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number32
DOIs
Publication statusPublished - Jul 27 2009

Keywords

  • Amphiphiles
  • Epitopes
  • Gels
  • Peptides
  • Self-assembly

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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