Abstract
Photocleavage of a 2-nitrobenzyl group in a bioactive peptide amphiphile containing the Arg-Gly-Asp (RGD) epitope triggers a sol-to-gel transition as nanospheres are converted to nanofibers (see picture). This morphological change enhances the bioactivity of the nanostructures surrounding cells in three dimensions.
| Original language | English |
|---|---|
| Pages (from-to) | 5946-5949 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 48 |
| Issue number | 32 |
| DOIs | |
| Publication status | Published - Jul 27 2009 |
Keywords
- Amphiphiles
- Epitopes
- Gels
- Peptides
- Self-assembly
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
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Cite this
Muraoka, T., Koh, C. Y., Cui, H., & Stupp, S. I. (2009). Light-triggered bioactivity in three dimensions. Angewandte Chemie - International Edition, 48(32), 5946-5949. https://doi.org/10.1002/anie.200901524