Light-triggered bioactivity in three dimensions

Takahiro Muraoka, Chung Yan Koh, Honggang Cui, Samuel I Stupp

Research output: Contribution to journal › Article

148 Citations (Scopus)

Abstract

Photocleavage of a 2-nitrobenzyl group in a bioactive peptide amphiphile containing the Arg-Gly-Asp (RGD) epitope triggers a sol-to-gel transition as nanospheres are converted to nanofibers (see picture). This morphological change enhances the bioactivity of the nanostructures surrounding cells in three dimensions.

Original languageEnglish
Pages (from-to)5946-5949
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number32
DOIs
Publication statusPublished - Jul 27 2009

Fingerprint

Nanospheres
Nanofibers
Epitopes
Amphiphiles
Nanostructures
Polymethyl Methacrylate
Sols
Bioactivity
Peptides
Gels
Light

Keywords

  • Amphiphiles
  • Epitopes
  • Gels
  • Peptides
  • Self-assembly

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)

Cite this

Light-triggered bioactivity in three dimensions. / Muraoka, Takahiro; Koh, Chung Yan; Cui, Honggang; Stupp, Samuel I.

In: Angewandte Chemie - International Edition, Vol. 48, No. 32, 27.07.2009, p. 5946-5949.

Research output: Contribution to journal › Article

Muraoka, T, Koh, CY, Cui, H & Stupp, SI 2009, 'Light-triggered bioactivity in three dimensions', Angewandte Chemie - International Edition, vol. 48, no. 32, pp. 5946-5949. https://doi.org/10.1002/anie.200901524
Muraoka T, Koh CY, Cui H, Stupp SI. Light-triggered bioactivity in three dimensions. Angewandte Chemie - International Edition. 2009 Jul 27;48(32):5946-5949. https://doi.org/10.1002/anie.200901524
Muraoka, Takahiro ; Koh, Chung Yan ; Cui, Honggang ; Stupp, Samuel I. / Light-triggered bioactivity in three dimensions. In: Angewandte Chemie - International Edition. 2009 ; Vol. 48, No. 32. pp. 5946-5949.
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