Light-triggered bioactivity in three dimensions

Takahiro Muraoka; Chung Yan Koh; Honggang Cui; Samuel I. Stupp

doi:10.1002/anie.200901524

Light-triggered bioactivity in three dimensions

Takahiro Muraoka, Chung Yan Koh, Honggang Cui, Samuel I. Stupp

Northwestern University

Research output: Contribution to journal › Article

154 Citations (Scopus)

Abstract

Photocleavage of a 2-nitrobenzyl group in a bioactive peptide amphiphile containing the Arg-Gly-Asp (RGD) epitope triggers a sol-to-gel transition as nanospheres are converted to nanofibers (see picture). This morphological change enhances the bioactivity of the nanostructures surrounding cells in three dimensions.

Original language	English
Pages (from-to)	5946-5949
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	32
DOIs	https://doi.org/10.1002/anie.200901524
Publication status	Published - Jul 27 2009

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Keywords

Amphiphiles
Epitopes
Gels
Peptides
Self-assembly

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Cite this

Muraoka, T., Koh, C. Y., Cui, H., & Stupp, S. I. (2009). Light-triggered bioactivity in three dimensions. Angewandte Chemie - International Edition, 48(32), 5946-5949. https://doi.org/10.1002/anie.200901524

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Access to Document

10.1002/anie.200901524