Lung toxicities of core-shell nanoparticles composed of carbon, cobalt, and silica

Mohammed T. Al Samri, Rafael Silva, Saeeda Almarzooqi, Alia Albawardi, Aws Rashad Diab Othman, Ruqayya S M S Al Hanjeri, Shaikha K M Al Dawaar, Saeed Tariq, Abdul Kader Souid, Teddy Asefa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We present here comparative assessments of murine lung toxicity (biocompatibility) after in vitro and in vivo exposures to carbon (C-SiO2-etched), carbon-silica (C-SiO2), carbon-cobalt-silica (C-Co-SiO2), and carbon-cobalt oxide-silica (C-Co3O4-SiO2) nanoparticles. These nanoparticles have potential applications in clinical medicine and bioimaging, and thus their possible adverse events require thorough investigation. The primary aim of this work was to explore whether the nanoparticles are biocompatible with pneumatocyte bioenergetics (cellular respiration and adenosine triphosphate content). Other objectives included assessments of caspase activity, lung structure, and cellular organelles. Pneumatocyte bioenergetics of murine lung remained preserved after treatment with C-SiO2-etched or C-SiO2 nanoparticles. C-SiO2-etched nanoparticles, however, increased caspase activity and altered lung structure more than C-SiO2 did. Consistent with the known mitochondrial toxicity of cobalt, both C-Co-SiO2 and C-Co3O4-SiO2 impaired lung tissue bioenergetics. C-Co-SiO2, however, increased caspase activity and altered lung structure more than C-Co3O4-SiO2. The results indicate that silica shell is essential for biocompatibility. Furthermore, cobalt oxide is the preferred phase over the zerovalent Co(0) phase to impart biocompatibility to cobalt-based nanoparticles.

Original languageEnglish
Pages (from-to)1223-1244
Number of pages22
JournalInternational Journal of Nanomedicine
Volume8
DOIs
Publication statusPublished - Mar 20 2013

Fingerprint

Cobalt
Silicon Dioxide
Nanoparticles
Toxicity
Carbon
Silica
Lung
Caspases
Biocompatibility
Energy Metabolism
Cell Respiration
Oxides
Clinical Medicine
Bioelectric potentials
Cellular Structures
Organelles
Medicine
Adenosine Triphosphate
Tissue

Keywords

  • Biocompatibility
  • Carbon nanoparticles
  • Cobalt nanoparticles
  • Cobalt oxide nanoparticles
  • Nanotoxicology
  • Silica nanoparticles

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Organic Chemistry
  • Drug Discovery

Cite this

Al Samri, M. T., Silva, R., Almarzooqi, S., Albawardi, A., Othman, A. R. D., Al Hanjeri, R. S. M. S., ... Asefa, T. (2013). Lung toxicities of core-shell nanoparticles composed of carbon, cobalt, and silica. International Journal of Nanomedicine, 8, 1223-1244. https://doi.org/10.2147/IJN.S39649

Lung toxicities of core-shell nanoparticles composed of carbon, cobalt, and silica. / Al Samri, Mohammed T.; Silva, Rafael; Almarzooqi, Saeeda; Albawardi, Alia; Othman, Aws Rashad Diab; Al Hanjeri, Ruqayya S M S; Al Dawaar, Shaikha K M; Tariq, Saeed; Souid, Abdul Kader; Asefa, Teddy.

In: International Journal of Nanomedicine, Vol. 8, 20.03.2013, p. 1223-1244.

Research output: Contribution to journalArticle

Al Samri, MT, Silva, R, Almarzooqi, S, Albawardi, A, Othman, ARD, Al Hanjeri, RSMS, Al Dawaar, SKM, Tariq, S, Souid, AK & Asefa, T 2013, 'Lung toxicities of core-shell nanoparticles composed of carbon, cobalt, and silica', International Journal of Nanomedicine, vol. 8, pp. 1223-1244. https://doi.org/10.2147/IJN.S39649
Al Samri MT, Silva R, Almarzooqi S, Albawardi A, Othman ARD, Al Hanjeri RSMS et al. Lung toxicities of core-shell nanoparticles composed of carbon, cobalt, and silica. International Journal of Nanomedicine. 2013 Mar 20;8:1223-1244. https://doi.org/10.2147/IJN.S39649
Al Samri, Mohammed T. ; Silva, Rafael ; Almarzooqi, Saeeda ; Albawardi, Alia ; Othman, Aws Rashad Diab ; Al Hanjeri, Ruqayya S M S ; Al Dawaar, Shaikha K M ; Tariq, Saeed ; Souid, Abdul Kader ; Asefa, Teddy. / Lung toxicities of core-shell nanoparticles composed of carbon, cobalt, and silica. In: International Journal of Nanomedicine. 2013 ; Vol. 8. pp. 1223-1244.
@article{1a1b9f5d9b164012a5d3dfd0121b0089,
title = "Lung toxicities of core-shell nanoparticles composed of carbon, cobalt, and silica",
abstract = "We present here comparative assessments of murine lung toxicity (biocompatibility) after in vitro and in vivo exposures to carbon (C-SiO2-etched), carbon-silica (C-SiO2), carbon-cobalt-silica (C-Co-SiO2), and carbon-cobalt oxide-silica (C-Co3O4-SiO2) nanoparticles. These nanoparticles have potential applications in clinical medicine and bioimaging, and thus their possible adverse events require thorough investigation. The primary aim of this work was to explore whether the nanoparticles are biocompatible with pneumatocyte bioenergetics (cellular respiration and adenosine triphosphate content). Other objectives included assessments of caspase activity, lung structure, and cellular organelles. Pneumatocyte bioenergetics of murine lung remained preserved after treatment with C-SiO2-etched or C-SiO2 nanoparticles. C-SiO2-etched nanoparticles, however, increased caspase activity and altered lung structure more than C-SiO2 did. Consistent with the known mitochondrial toxicity of cobalt, both C-Co-SiO2 and C-Co3O4-SiO2 impaired lung tissue bioenergetics. C-Co-SiO2, however, increased caspase activity and altered lung structure more than C-Co3O4-SiO2. The results indicate that silica shell is essential for biocompatibility. Furthermore, cobalt oxide is the preferred phase over the zerovalent Co(0) phase to impart biocompatibility to cobalt-based nanoparticles.",
keywords = "Biocompatibility, Carbon nanoparticles, Cobalt nanoparticles, Cobalt oxide nanoparticles, Nanotoxicology, Silica nanoparticles",
author = "{Al Samri}, {Mohammed T.} and Rafael Silva and Saeeda Almarzooqi and Alia Albawardi and Othman, {Aws Rashad Diab} and {Al Hanjeri}, {Ruqayya S M S} and {Al Dawaar}, {Shaikha K M} and Saeed Tariq and Souid, {Abdul Kader} and Teddy Asefa",
year = "2013",
month = "3",
day = "20",
doi = "10.2147/IJN.S39649",
language = "English",
volume = "8",
pages = "1223--1244",
journal = "International Journal of Nanomedicine",
issn = "1176-9114",
publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Lung toxicities of core-shell nanoparticles composed of carbon, cobalt, and silica

AU - Al Samri, Mohammed T.

AU - Silva, Rafael

AU - Almarzooqi, Saeeda

AU - Albawardi, Alia

AU - Othman, Aws Rashad Diab

AU - Al Hanjeri, Ruqayya S M S

AU - Al Dawaar, Shaikha K M

AU - Tariq, Saeed

AU - Souid, Abdul Kader

AU - Asefa, Teddy

PY - 2013/3/20

Y1 - 2013/3/20

N2 - We present here comparative assessments of murine lung toxicity (biocompatibility) after in vitro and in vivo exposures to carbon (C-SiO2-etched), carbon-silica (C-SiO2), carbon-cobalt-silica (C-Co-SiO2), and carbon-cobalt oxide-silica (C-Co3O4-SiO2) nanoparticles. These nanoparticles have potential applications in clinical medicine and bioimaging, and thus their possible adverse events require thorough investigation. The primary aim of this work was to explore whether the nanoparticles are biocompatible with pneumatocyte bioenergetics (cellular respiration and adenosine triphosphate content). Other objectives included assessments of caspase activity, lung structure, and cellular organelles. Pneumatocyte bioenergetics of murine lung remained preserved after treatment with C-SiO2-etched or C-SiO2 nanoparticles. C-SiO2-etched nanoparticles, however, increased caspase activity and altered lung structure more than C-SiO2 did. Consistent with the known mitochondrial toxicity of cobalt, both C-Co-SiO2 and C-Co3O4-SiO2 impaired lung tissue bioenergetics. C-Co-SiO2, however, increased caspase activity and altered lung structure more than C-Co3O4-SiO2. The results indicate that silica shell is essential for biocompatibility. Furthermore, cobalt oxide is the preferred phase over the zerovalent Co(0) phase to impart biocompatibility to cobalt-based nanoparticles.

AB - We present here comparative assessments of murine lung toxicity (biocompatibility) after in vitro and in vivo exposures to carbon (C-SiO2-etched), carbon-silica (C-SiO2), carbon-cobalt-silica (C-Co-SiO2), and carbon-cobalt oxide-silica (C-Co3O4-SiO2) nanoparticles. These nanoparticles have potential applications in clinical medicine and bioimaging, and thus their possible adverse events require thorough investigation. The primary aim of this work was to explore whether the nanoparticles are biocompatible with pneumatocyte bioenergetics (cellular respiration and adenosine triphosphate content). Other objectives included assessments of caspase activity, lung structure, and cellular organelles. Pneumatocyte bioenergetics of murine lung remained preserved after treatment with C-SiO2-etched or C-SiO2 nanoparticles. C-SiO2-etched nanoparticles, however, increased caspase activity and altered lung structure more than C-SiO2 did. Consistent with the known mitochondrial toxicity of cobalt, both C-Co-SiO2 and C-Co3O4-SiO2 impaired lung tissue bioenergetics. C-Co-SiO2, however, increased caspase activity and altered lung structure more than C-Co3O4-SiO2. The results indicate that silica shell is essential for biocompatibility. Furthermore, cobalt oxide is the preferred phase over the zerovalent Co(0) phase to impart biocompatibility to cobalt-based nanoparticles.

KW - Biocompatibility

KW - Carbon nanoparticles

KW - Cobalt nanoparticles

KW - Cobalt oxide nanoparticles

KW - Nanotoxicology

KW - Silica nanoparticles

UR - http://www.scopus.com/inward/record.url?scp=84875552618&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875552618&partnerID=8YFLogxK

U2 - 10.2147/IJN.S39649

DO - 10.2147/IJN.S39649

M3 - Article

C2 - 23658487

AN - SCOPUS:84875552618

VL - 8

SP - 1223

EP - 1244

JO - International Journal of Nanomedicine

JF - International Journal of Nanomedicine

SN - 1176-9114

ER -