Magnetic resonance imaging of self-assembled biomaterial scaffolds

Steve R. Bull, Mustafa O. Guler, Rafael E. Bras, Palamadai N. Venkatasubramanian, Samuel I Stupp, Thomas J. Meade

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Current interest in biomaterials for tissue engineering and drug delivery applications have spurred research into self-assembling peptide amphiphiles (PAs). Nanofiber networks formed from self-assembling PAs can be used as biomaterial scaffolds with the advantage of specificity by the incorporation of peptide-epitopes. Imaging the materials noninvasively will give information as to their fate in vivo. We report here the synthesis and in vitro MR images of self-assembling peptide amphiphile contrast agents (PACAs) that form nanofibers. At 400 MHz using a 0.1 mM Gd(III) conjugate of the PA we observed a TI three times that of a control gel. The PA derivative was doped into various epitope bearing PA solutions and upon gelling resulted in a homogeneous biomaterial as imaged by MRI.

Original languageEnglish
Pages (from-to)1343-1348
Number of pages6
JournalBioconjugate Chemistry
Volume16
Issue number6
DOIs
Publication statusPublished - Nov 2005

Fingerprint

Biocompatible Materials
Amphiphiles
Scaffolds (biology)
Biomaterials
Magnetic resonance imaging
Peptides
Magnetic Resonance Imaging
Nanofibers
Epitopes
Bearings (structural)
Tissue Engineering
Drug delivery
Tissue engineering
Scaffolds
Contrast Media
Gels
Derivatives
Imaging techniques
Research
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Clinical Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Bull, S. R., Guler, M. O., Bras, R. E., Venkatasubramanian, P. N., Stupp, S. I., & Meade, T. J. (2005). Magnetic resonance imaging of self-assembled biomaterial scaffolds. Bioconjugate Chemistry, 16(6), 1343-1348. https://doi.org/10.1021/bc050153h

Magnetic resonance imaging of self-assembled biomaterial scaffolds. / Bull, Steve R.; Guler, Mustafa O.; Bras, Rafael E.; Venkatasubramanian, Palamadai N.; Stupp, Samuel I; Meade, Thomas J.

In: Bioconjugate Chemistry, Vol. 16, No. 6, 11.2005, p. 1343-1348.

Research output: Contribution to journalArticle

Bull, SR, Guler, MO, Bras, RE, Venkatasubramanian, PN, Stupp, SI & Meade, TJ 2005, 'Magnetic resonance imaging of self-assembled biomaterial scaffolds', Bioconjugate Chemistry, vol. 16, no. 6, pp. 1343-1348. https://doi.org/10.1021/bc050153h
Bull SR, Guler MO, Bras RE, Venkatasubramanian PN, Stupp SI, Meade TJ. Magnetic resonance imaging of self-assembled biomaterial scaffolds. Bioconjugate Chemistry. 2005 Nov;16(6):1343-1348. https://doi.org/10.1021/bc050153h
Bull, Steve R. ; Guler, Mustafa O. ; Bras, Rafael E. ; Venkatasubramanian, Palamadai N. ; Stupp, Samuel I ; Meade, Thomas J. / Magnetic resonance imaging of self-assembled biomaterial scaffolds. In: Bioconjugate Chemistry. 2005 ; Vol. 16, No. 6. pp. 1343-1348.
@article{92aee4ad87be4f46814b1b790b656b85,
title = "Magnetic resonance imaging of self-assembled biomaterial scaffolds",
abstract = "Current interest in biomaterials for tissue engineering and drug delivery applications have spurred research into self-assembling peptide amphiphiles (PAs). Nanofiber networks formed from self-assembling PAs can be used as biomaterial scaffolds with the advantage of specificity by the incorporation of peptide-epitopes. Imaging the materials noninvasively will give information as to their fate in vivo. We report here the synthesis and in vitro MR images of self-assembling peptide amphiphile contrast agents (PACAs) that form nanofibers. At 400 MHz using a 0.1 mM Gd(III) conjugate of the PA we observed a TI three times that of a control gel. The PA derivative was doped into various epitope bearing PA solutions and upon gelling resulted in a homogeneous biomaterial as imaged by MRI.",
author = "Bull, {Steve R.} and Guler, {Mustafa O.} and Bras, {Rafael E.} and Venkatasubramanian, {Palamadai N.} and Stupp, {Samuel I} and Meade, {Thomas J.}",
year = "2005",
month = "11",
doi = "10.1021/bc050153h",
language = "English",
volume = "16",
pages = "1343--1348",
journal = "Bioconjugate Chemistry",
issn = "1043-1802",
publisher = "American Chemical Society",
number = "6",

}

TY - JOUR

T1 - Magnetic resonance imaging of self-assembled biomaterial scaffolds

AU - Bull, Steve R.

AU - Guler, Mustafa O.

AU - Bras, Rafael E.

AU - Venkatasubramanian, Palamadai N.

AU - Stupp, Samuel I

AU - Meade, Thomas J.

PY - 2005/11

Y1 - 2005/11

N2 - Current interest in biomaterials for tissue engineering and drug delivery applications have spurred research into self-assembling peptide amphiphiles (PAs). Nanofiber networks formed from self-assembling PAs can be used as biomaterial scaffolds with the advantage of specificity by the incorporation of peptide-epitopes. Imaging the materials noninvasively will give information as to their fate in vivo. We report here the synthesis and in vitro MR images of self-assembling peptide amphiphile contrast agents (PACAs) that form nanofibers. At 400 MHz using a 0.1 mM Gd(III) conjugate of the PA we observed a TI three times that of a control gel. The PA derivative was doped into various epitope bearing PA solutions and upon gelling resulted in a homogeneous biomaterial as imaged by MRI.

AB - Current interest in biomaterials for tissue engineering and drug delivery applications have spurred research into self-assembling peptide amphiphiles (PAs). Nanofiber networks formed from self-assembling PAs can be used as biomaterial scaffolds with the advantage of specificity by the incorporation of peptide-epitopes. Imaging the materials noninvasively will give information as to their fate in vivo. We report here the synthesis and in vitro MR images of self-assembling peptide amphiphile contrast agents (PACAs) that form nanofibers. At 400 MHz using a 0.1 mM Gd(III) conjugate of the PA we observed a TI three times that of a control gel. The PA derivative was doped into various epitope bearing PA solutions and upon gelling resulted in a homogeneous biomaterial as imaged by MRI.

UR - http://www.scopus.com/inward/record.url?scp=27944461032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27944461032&partnerID=8YFLogxK

U2 - 10.1021/bc050153h

DO - 10.1021/bc050153h

M3 - Article

VL - 16

SP - 1343

EP - 1348

JO - Bioconjugate Chemistry

JF - Bioconjugate Chemistry

SN - 1043-1802

IS - 6

ER -