Manganese-Catalyzed α-Alkylation of Ketones, Esters, and Amides Using Alcohols

Subrata Chakraborty, Prosenjit Daw, Yehoshoa Ben David, David Milstein

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Herein we report the manganese-catalyzed C-C bond-forming reactions via α-alkylation of ketones, amides, and esters, using primary alcohols. β-Alkylation of secondary alcohols by primary alcohols to obtain α-alkylated ketones is also reported. The reactions are catalyzed by a (iPr-PNP)Mn(H)(CO)2 pincer complex under mild conditions in the presence of (catalytic) base liberating water (and H2 in the case of secondary alcohol alkylation) as the sole byproduct.

Original languageEnglish
Pages (from-to)10300-10305
Number of pages6
JournalACS Catalysis
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Alkylation
Manganese
Ketones
Amides
Esters
Alcohols
Carbon Monoxide
Byproducts
Water

Keywords

  • alkylation
  • amides
  • esters
  • ketones
  • manganese
  • pincer
  • secondary alcohol

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Manganese-Catalyzed α-Alkylation of Ketones, Esters, and Amides Using Alcohols. / Chakraborty, Subrata; Daw, Prosenjit; Ben David, Yehoshoa; Milstein, David.

In: ACS Catalysis, 01.01.2018, p. 10300-10305.

Research output: Contribution to journalArticle

Chakraborty, Subrata ; Daw, Prosenjit ; Ben David, Yehoshoa ; Milstein, David. / Manganese-Catalyzed α-Alkylation of Ketones, Esters, and Amides Using Alcohols. In: ACS Catalysis. 2018 ; pp. 10300-10305.
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