Manganese-Catalyzed α-Alkylation of Ketones, Esters, and Amides Using Alcohols

Subrata Chakraborty, Prosenjit Daw, Yehoshoa Ben David, David Milstein

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Herein we report the manganese-catalyzed C-C bond-forming reactions via α-alkylation of ketones, amides, and esters, using primary alcohols. β-Alkylation of secondary alcohols by primary alcohols to obtain α-alkylated ketones is also reported. The reactions are catalyzed by a (iPr-PNP)Mn(H)(CO)2 pincer complex under mild conditions in the presence of (catalytic) base liberating water (and H2 in the case of secondary alcohol alkylation) as the sole byproduct.

Original languageEnglish
Pages (from-to)10300-10305
Number of pages6
JournalACS Catalysis
Volume8
Issue number11
DOIs
Publication statusPublished - Nov 2 2018

Keywords

  • alkylation
  • amides
  • esters
  • ketones
  • manganese
  • pincer
  • secondary alcohol

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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