Manganese-Catalyzed Direct Deoxygenation of Primary Alcohols

Jonathan O. Bauer; Subrata Chakraborty; David Milstein

doi:10.1021/acscatal.7b01729

Manganese-Catalyzed Direct Deoxygenation of Primary Alcohols

Jonathan O. Bauer, Subrata Chakraborty, David Milstein

Weizmann Institute of Science, Israel

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Deoxygenation of alcohols is an important tool in the repertoire of defunctionalization methods in modern synthetic chemistry. We report the base-metal-catalyzed direct deoxygenation of benzylic and aliphatic primary alcohols via oxidative dehydrogenation/Wolff-Kishner reduction. The reaction is catalyzed by a well-defined PNP pincer complex of Earth-abundant manganese, evolving H₂, N₂, and water as the only byproducts.

Original language	English
Pages (from-to)	4462-4466
Number of pages	5
Journal	ACS Catalysis
Volume	7
Issue number	7
DOIs	https://doi.org/10.1021/acscatal.7b01729
Publication status	Published - Jul 7 2017

Keywords

alcohols
deoxygenation
homogeneous catalysis
manganese complex
pincer complexes

ASJC Scopus subject areas

Catalysis

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10.1021/acscatal.7b01729

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AU - Milstein, David

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N2 - Deoxygenation of alcohols is an important tool in the repertoire of defunctionalization methods in modern synthetic chemistry. We report the base-metal-catalyzed direct deoxygenation of benzylic and aliphatic primary alcohols via oxidative dehydrogenation/Wolff-Kishner reduction. The reaction is catalyzed by a well-defined PNP pincer complex of Earth-abundant manganese, evolving H2, N2, and water as the only byproducts.

AB - Deoxygenation of alcohols is an important tool in the repertoire of defunctionalization methods in modern synthetic chemistry. We report the base-metal-catalyzed direct deoxygenation of benzylic and aliphatic primary alcohols via oxidative dehydrogenation/Wolff-Kishner reduction. The reaction is catalyzed by a well-defined PNP pincer complex of Earth-abundant manganese, evolving H2, N2, and water as the only byproducts.

KW - alcohols

KW - deoxygenation

KW - homogeneous catalysis

KW - manganese complex

KW - pincer complexes

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