Manganese-Catalyzed Environmentally Benign Dehydrogenative Coupling of Alcohols and Amines to Form Aldimines and H2: A Catalytic and Mechanistic Study

Arup Mukherjee, Alexander Nerush, Gregory Leitus, Linda J W Shimon, Yehoshoa Ben David, Noel Angel Espinosa Jalapa, David Milstein

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The catalytic dehydrogenative coupling of alcohols and amines to form aldimines represents an environmentally benign methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts. We present the dehydrogenative coupling of alcohols and amines to form imines and H2 that is catalyzed, for the first time, by a complex of the earth-abundant Mn. Detailed mechanistic study was carried out with the aid of NMR spectroscopy, intermediate isolation, and X-ray analysis.

Original languageEnglish
Pages (from-to)4298-4301
Number of pages4
JournalJournal of the American Chemical Society
Issue number13
Publication statusPublished - Apr 20 2016


ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

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