Manganese-Catalyzed Environmentally Benign Dehydrogenative Coupling of Alcohols and Amines to Form Aldimines and H2: A Catalytic and Mechanistic Study

Arup Mukherjee, Alexander Nerush, Gregory Leitus, Linda J W Shimon, Yehoshoa Ben David, Noel Angel Espinosa Jalapa, David Milstein

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203 Citations (Scopus)

Abstract

The catalytic dehydrogenative coupling of alcohols and amines to form aldimines represents an environmentally benign methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts. We present the dehydrogenative coupling of alcohols and amines to form imines and H2 that is catalyzed, for the first time, by a complex of the earth-abundant Mn. Detailed mechanistic study was carried out with the aid of NMR spectroscopy, intermediate isolation, and X-ray analysis.

Original languageEnglish
Pages (from-to)4298-4301
Number of pages4
JournalJournal of the American Chemical Society
Volume138
Issue number13
DOIs
Publication statusPublished - Apr 20 2016

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ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

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