TY - JOUR
T1 - Manganese Catalyzed Hydrogenation of Carbamates and Urea Derivatives
AU - Das, Uttam Kumar
AU - Kumar, Amit
AU - Ben-David, Yehoshoa
AU - Iron, Mark A.
AU - Milstein, David
N1 - Funding Information:
This research was supported by the European Research Council (ERC AdG 692775), and by the Israel Science Foundation. U.K.D. is thankful to Gov’t. of India for the DST SERB Overseas Postdoctoral Fellowship.
PY - 2019/8/21
Y1 - 2019/8/21
N2 - We report the hydrogenation of carbamates and urea derivatives, two of the most challenging carbonyl compounds to be hydrogenated, catalyzed for the first time by a complex of an earth-abundant metal. The hydrogenation reaction of these CO2-derived compounds, catalyzed by a manganese pincer complex, yields methanol in addition to amine and alcohol, which makes this methodology a sustainable alternative route for the conversion of CO2 to methanol, involving a base-metal catalyst. Moreover, the hydrogenation proceeds under mild pressure (20 bar). Our observations support a hydrogenation mechanism involving the Mn-H complex. A plausible catalytic cycle is proposed based on informative mechanistic experiments.
AB - We report the hydrogenation of carbamates and urea derivatives, two of the most challenging carbonyl compounds to be hydrogenated, catalyzed for the first time by a complex of an earth-abundant metal. The hydrogenation reaction of these CO2-derived compounds, catalyzed by a manganese pincer complex, yields methanol in addition to amine and alcohol, which makes this methodology a sustainable alternative route for the conversion of CO2 to methanol, involving a base-metal catalyst. Moreover, the hydrogenation proceeds under mild pressure (20 bar). Our observations support a hydrogenation mechanism involving the Mn-H complex. A plausible catalytic cycle is proposed based on informative mechanistic experiments.
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U2 - 10.1021/jacs.9b05591
DO - 10.1021/jacs.9b05591
M3 - Article
C2 - 31365248
AN - SCOPUS:85070967852
VL - 141
SP - 12962
EP - 12966
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 33
ER -