Manganese-Catalyzed N-Formylation of Amines by Methanol Liberating H2: A Catalytic and Mechanistic Study

Subrata Chakraborty, Urs Gellrich, Yael Diskin-Posner, Gregory Leitus, Liat Avram, David Milstein

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

The first example of a base metal (manganese) catalyzed acceptorless dehydrogenative coupling of methanol and amines to form formamides is reported herein. The novel pincer complex (iPr-PNHP)Mn(H)(CO)2 catalyzes the reaction under mild conditions in the absence of any additives, bases, or hydrogen acceptors. Mechanistic insight based on the observation of an intermediate and DFT calculations is also provided.

Original languageEnglish
Pages (from-to)4229-4233
Number of pages5
JournalAngewandte Chemie - International Edition
Volume56
Issue number15
DOIs
Publication statusPublished - Apr 3 2017

Keywords

  • dehydrogenation
  • formylation
  • manganese
  • methanol
  • pincer complexes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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