Marine animal biosynthetic constituents for cancer chemotherapy

George R. Pettit, Yoshiaki Kamano, Youichi Fujii, Cherry L. Herald, Masuo Inoue, Peter Brown, John Devens Gust, Keiichi Kitahara, Jean M. Schmidt, Dennis L. Doubek, Claude Michel

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Abstract

A fifteen year investigation of marine animal components as sources for new and potentially useful cancer chemotherapeutic drugs has led to our discovery of a number of such valuable substances. The especially productive Indian Ocean sea hare Dolabella auricularia has yielded (100 kg→∼1 mg each) a series of very potent cell growth inhibitory substances designated dolastatins 1-9. The first member of this new series, dolastatin 1, may represent the most potent anticancer agent so far uncovered with, e.g., a curative response (33%) using a dose of 11 μg/kg (T/C 240, to T/C 139 at 1.37 μg/kg) in the National Cancer Institute's murine B16 melanoma. Structural elucidation of the new antineoplastic agents is underway, and recent progress is illustrated with the peptide dolastatin 3 (P388 ED50 2.7 ×10-7 μg/ml).

Original languageEnglish
Pages (from-to)482-485
Number of pages4
JournalJournal of Natural Products
Volume44
Issue number4
Publication statusPublished - 1981

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ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Pettit, G. R., Kamano, Y., Fujii, Y., Herald, C. L., Inoue, M., Brown, P., Gust, J. D., Kitahara, K., Schmidt, J. M., Doubek, D. L., & Michel, C. (1981). Marine animal biosynthetic constituents for cancer chemotherapy. Journal of Natural Products, 44(4), 482-485.