Abstract
The solubility of febuxostat in ethyl acetate, methanol, ethanol, and acetone was determined respectively by the gravimetric method from (293.15 to 328.15) K under atmospheric pressure, and the experimental data were well-correlated by the Apelblat and van't Hoff equations. The experimental solubility data and their correlation equation obtained would be useful for the solvent selection of febuxostat crystallization.
| Original language | English |
|---|---|
| Pages (from-to) | 3149-3152 |
| Number of pages | 4 |
| Journal | Journal of Chemical and Engineering Data |
| Volume | 57 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 8 2012 |
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ASJC Scopus subject areas
- Chemistry(all)
- Chemical Engineering(all)
Cite this
Measurement and correlation of the solubility of febuxostat in four organic solvents at various temperatures. / Zhang, Lei; Huang, Zhiping; Wan, Xiaoran; Li, Jing; Liu, Jing.
In: Journal of Chemical and Engineering Data, Vol. 57, No. 11, 08.11.2012, p. 3149-3152.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Measurement and correlation of the solubility of febuxostat in four organic solvents at various temperatures
AU - Zhang, Lei
AU - Huang, Zhiping
AU - Wan, Xiaoran
AU - Li, Jing
AU - Liu, Jing
PY - 2012/11/8
Y1 - 2012/11/8
N2 - The solubility of febuxostat in ethyl acetate, methanol, ethanol, and acetone was determined respectively by the gravimetric method from (293.15 to 328.15) K under atmospheric pressure, and the experimental data were well-correlated by the Apelblat and van't Hoff equations. The experimental solubility data and their correlation equation obtained would be useful for the solvent selection of febuxostat crystallization.
AB - The solubility of febuxostat in ethyl acetate, methanol, ethanol, and acetone was determined respectively by the gravimetric method from (293.15 to 328.15) K under atmospheric pressure, and the experimental data were well-correlated by the Apelblat and van't Hoff equations. The experimental solubility data and their correlation equation obtained would be useful for the solvent selection of febuxostat crystallization.
UR - http://www.scopus.com/inward/record.url?scp=84868695221&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84868695221&partnerID=8YFLogxK
U2 - 10.1021/je300647k
DO - 10.1021/je300647k
M3 - Article
AN - SCOPUS:84868695221
VL - 57
SP - 3149
EP - 3152
JO - Journal of Chemical & Engineering Data
JF - Journal of Chemical & Engineering Data
SN - 0021-9568
IS - 11
ER -