Measurement and correlation of the solubility of febuxostat in four organic solvents at various temperatures

Lei Zhang, Zhiping Huang, Xiaoran Wan, Jing Li, Jing Liu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The solubility of febuxostat in ethyl acetate, methanol, ethanol, and acetone was determined respectively by the gravimetric method from (293.15 to 328.15) K under atmospheric pressure, and the experimental data were well-correlated by the Apelblat and van't Hoff equations. The experimental solubility data and their correlation equation obtained would be useful for the solvent selection of febuxostat crystallization.

Original languageEnglish
Pages (from-to)3149-3152
Number of pages4
JournalJournal of Chemical and Engineering Data
Volume57
Issue number11
DOIs
Publication statusPublished - Nov 8 2012

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Organic solvents
Solubility
Acetone
Crystallization
Atmospheric pressure
Methanol
Ethanol
Temperature
Febuxostat
ethyl acetate

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Measurement and correlation of the solubility of febuxostat in four organic solvents at various temperatures. / Zhang, Lei; Huang, Zhiping; Wan, Xiaoran; Li, Jing; Liu, Jing.

In: Journal of Chemical and Engineering Data, Vol. 57, No. 11, 08.11.2012, p. 3149-3152.

Research output: Contribution to journalArticle

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