Measurement and correlation of the solubility of febuxostat in four organic solvents at various temperatures

Lei Zhang; Zhiping Huang; Xiaoran Wan; Jing Li; Jing Liu

doi:10.1021/je300647k

Measurement and correlation of the solubility of febuxostat in four organic solvents at various temperatures

Lei Zhang, Zhiping Huang, Xiaoran Wan, Jing Li, Jing Liu

Rutgers University

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

The solubility of febuxostat in ethyl acetate, methanol, ethanol, and acetone was determined respectively by the gravimetric method from (293.15 to 328.15) K under atmospheric pressure, and the experimental data were well-correlated by the Apelblat and van't Hoff equations. The experimental solubility data and their correlation equation obtained would be useful for the solvent selection of febuxostat crystallization.

Original language	English
Pages (from-to)	3149-3152
Number of pages	4
Journal	Journal of Chemical and Engineering Data
Volume	57
Issue number	11
DOIs	https://doi.org/10.1021/je300647k
Publication status	Published - Nov 8 2012

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

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AU - Huang, Zhiping

AU - Wan, Xiaoran

AU - Li, Jing

AU - Liu, Jing

PY - 2012/11/8

Y1 - 2012/11/8

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AB - The solubility of febuxostat in ethyl acetate, methanol, ethanol, and acetone was determined respectively by the gravimetric method from (293.15 to 328.15) K under atmospheric pressure, and the experimental data were well-correlated by the Apelblat and van't Hoff equations. The experimental solubility data and their correlation equation obtained would be useful for the solvent selection of febuxostat crystallization.

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Measurement and correlation of the solubility of febuxostat in four organic solvents at various temperatures

Abstract

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