Mechanistic investigation of intramolecular aminoalkene and aminoalkyne hydroamination/cyclization catalyzed by highly electrophilic, tetravalent constrained geometry 4d and 5f complexes. Evidence for an M-N σ-bonded insertive pathway

Bryan D. Stubbert, Tobin J Marks

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Abstract

A mechanistic study of intramolecular hydroamination/cyclization catalyzed by tetravalent organoactinide and organozirconium complexes is presented. A series of selectively substituted constrained geometry complexes, (CGC)M(NR 2)Cl (CGC = [Me2Si(η5-Me4C 5)(tBuN)]2-; M = Th, 1-Cl; U, 2-Cl; R = SiMe3; M = Zr, R = Me, 3-Cl) and (CGC)An(NMe2)OAr (An = Th, 1-OAr; An = U, 2-OAr), has been prepared via in situ protodeamination (complexes 1-2) or salt metathesis (3-Cl) in high purity and excellent yield and is found to be active precatalysts for intramolecular primary and secondary aminoalkyne and aminoalkene hydroamination/cyclization. Substrate reactivity trends, rate laws, and activation parameters for cyclizations mediated by these complexes are virtually identical to those of more conventional (CGC)-MR 2 (M = Th, R = NMe2, 1; M = U, R = NMe2, 2; M = Zr, R = Me, 3), (Me2SiCp″2)UBn2 (Cp″ = η5-Me4C5; Bn = CH 2Ph, 4), Cp′2AnR2 (Cp′ = η5-Me5C5; R = CH2SiMe 3; An = Th, 5, U, 6), and analogous organolanthanide complexes. Deuterium KIEs measured at 25°C in C6D6 for aminoalkene D2NCH2C(CH3)2-CH 2CHCH2 (11-d2) with precatalysts 2 and 2-Cl indicate that kH/kD = 3.3(5) and 2.6(4), respectively. Together, the data provide strong evidence in these systems for turnover-limiting C-C insertion into an M-N(H)R σ-bond in the transition state. Related complexes (Me2SiCp″2)U(Bn)(Cl) (4-Cl) and Cp′2An(R)-(Cl) (R = CH2(SiMe3); An = Th, 5-Cl; An = U, 6-Cl) are also found to be effective precatalysts for this transformation. Additional arguments supporting M-N(H)R intermediates vs M=NR intermediates are presented.

Original languageEnglish
Pages (from-to)6149-6167
Number of pages19
JournalJournal of the American Chemical Society
Volume129
Issue number19
DOIs
Publication statusPublished - May 16 2007

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Cyclization
Geometry
Deuterium
Salts
Chemical activation
Substrates

ASJC Scopus subject areas

  • Chemistry(all)

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@article{9bfd52457704499b96a0d976f983604f,
title = "Mechanistic investigation of intramolecular aminoalkene and aminoalkyne hydroamination/cyclization catalyzed by highly electrophilic, tetravalent constrained geometry 4d and 5f complexes. Evidence for an M-N σ-bonded insertive pathway",
abstract = "A mechanistic study of intramolecular hydroamination/cyclization catalyzed by tetravalent organoactinide and organozirconium complexes is presented. A series of selectively substituted constrained geometry complexes, (CGC)M(NR 2)Cl (CGC = [Me2Si(η5-Me4C 5)(tBuN)]2-; M = Th, 1-Cl; U, 2-Cl; R = SiMe3; M = Zr, R = Me, 3-Cl) and (CGC)An(NMe2)OAr (An = Th, 1-OAr; An = U, 2-OAr), has been prepared via in situ protodeamination (complexes 1-2) or salt metathesis (3-Cl) in high purity and excellent yield and is found to be active precatalysts for intramolecular primary and secondary aminoalkyne and aminoalkene hydroamination/cyclization. Substrate reactivity trends, rate laws, and activation parameters for cyclizations mediated by these complexes are virtually identical to those of more conventional (CGC)-MR 2 (M = Th, R = NMe2, 1; M = U, R = NMe2, 2; M = Zr, R = Me, 3), (Me2SiCp″2)UBn2 (Cp″ = η5-Me4C5; Bn = CH 2Ph, 4), Cp′2AnR2 (Cp′ = η5-Me5C5; R = CH2SiMe 3; An = Th, 5, U, 6), and analogous organolanthanide complexes. Deuterium KIEs measured at 25°C in C6D6 for aminoalkene D2NCH2C(CH3)2-CH 2CHCH2 (11-d2) with precatalysts 2 and 2-Cl indicate that kH/kD = 3.3(5) and 2.6(4), respectively. Together, the data provide strong evidence in these systems for turnover-limiting C-C insertion into an M-N(H)R σ-bond in the transition state. Related complexes (Me2SiCp″2)U(Bn)(Cl) (4-Cl) and Cp′2An(R)-(Cl) (R = CH2(SiMe3); An = Th, 5-Cl; An = U, 6-Cl) are also found to be effective precatalysts for this transformation. Additional arguments supporting M-N(H)R intermediates vs M=NR intermediates are presented.",
author = "Stubbert, {Bryan D.} and Marks, {Tobin J}",
year = "2007",
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doi = "10.1021/ja0675898",
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journal = "Journal of the American Chemical Society",
issn = "0002-7863",
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TY - JOUR

T1 - Mechanistic investigation of intramolecular aminoalkene and aminoalkyne hydroamination/cyclization catalyzed by highly electrophilic, tetravalent constrained geometry 4d and 5f complexes. Evidence for an M-N σ-bonded insertive pathway

AU - Stubbert, Bryan D.

AU - Marks, Tobin J

PY - 2007/5/16

Y1 - 2007/5/16

N2 - A mechanistic study of intramolecular hydroamination/cyclization catalyzed by tetravalent organoactinide and organozirconium complexes is presented. A series of selectively substituted constrained geometry complexes, (CGC)M(NR 2)Cl (CGC = [Me2Si(η5-Me4C 5)(tBuN)]2-; M = Th, 1-Cl; U, 2-Cl; R = SiMe3; M = Zr, R = Me, 3-Cl) and (CGC)An(NMe2)OAr (An = Th, 1-OAr; An = U, 2-OAr), has been prepared via in situ protodeamination (complexes 1-2) or salt metathesis (3-Cl) in high purity and excellent yield and is found to be active precatalysts for intramolecular primary and secondary aminoalkyne and aminoalkene hydroamination/cyclization. Substrate reactivity trends, rate laws, and activation parameters for cyclizations mediated by these complexes are virtually identical to those of more conventional (CGC)-MR 2 (M = Th, R = NMe2, 1; M = U, R = NMe2, 2; M = Zr, R = Me, 3), (Me2SiCp″2)UBn2 (Cp″ = η5-Me4C5; Bn = CH 2Ph, 4), Cp′2AnR2 (Cp′ = η5-Me5C5; R = CH2SiMe 3; An = Th, 5, U, 6), and analogous organolanthanide complexes. Deuterium KIEs measured at 25°C in C6D6 for aminoalkene D2NCH2C(CH3)2-CH 2CHCH2 (11-d2) with precatalysts 2 and 2-Cl indicate that kH/kD = 3.3(5) and 2.6(4), respectively. Together, the data provide strong evidence in these systems for turnover-limiting C-C insertion into an M-N(H)R σ-bond in the transition state. Related complexes (Me2SiCp″2)U(Bn)(Cl) (4-Cl) and Cp′2An(R)-(Cl) (R = CH2(SiMe3); An = Th, 5-Cl; An = U, 6-Cl) are also found to be effective precatalysts for this transformation. Additional arguments supporting M-N(H)R intermediates vs M=NR intermediates are presented.

AB - A mechanistic study of intramolecular hydroamination/cyclization catalyzed by tetravalent organoactinide and organozirconium complexes is presented. A series of selectively substituted constrained geometry complexes, (CGC)M(NR 2)Cl (CGC = [Me2Si(η5-Me4C 5)(tBuN)]2-; M = Th, 1-Cl; U, 2-Cl; R = SiMe3; M = Zr, R = Me, 3-Cl) and (CGC)An(NMe2)OAr (An = Th, 1-OAr; An = U, 2-OAr), has been prepared via in situ protodeamination (complexes 1-2) or salt metathesis (3-Cl) in high purity and excellent yield and is found to be active precatalysts for intramolecular primary and secondary aminoalkyne and aminoalkene hydroamination/cyclization. Substrate reactivity trends, rate laws, and activation parameters for cyclizations mediated by these complexes are virtually identical to those of more conventional (CGC)-MR 2 (M = Th, R = NMe2, 1; M = U, R = NMe2, 2; M = Zr, R = Me, 3), (Me2SiCp″2)UBn2 (Cp″ = η5-Me4C5; Bn = CH 2Ph, 4), Cp′2AnR2 (Cp′ = η5-Me5C5; R = CH2SiMe 3; An = Th, 5, U, 6), and analogous organolanthanide complexes. Deuterium KIEs measured at 25°C in C6D6 for aminoalkene D2NCH2C(CH3)2-CH 2CHCH2 (11-d2) with precatalysts 2 and 2-Cl indicate that kH/kD = 3.3(5) and 2.6(4), respectively. Together, the data provide strong evidence in these systems for turnover-limiting C-C insertion into an M-N(H)R σ-bond in the transition state. Related complexes (Me2SiCp″2)U(Bn)(Cl) (4-Cl) and Cp′2An(R)-(Cl) (R = CH2(SiMe3); An = Th, 5-Cl; An = U, 6-Cl) are also found to be effective precatalysts for this transformation. Additional arguments supporting M-N(H)R intermediates vs M=NR intermediates are presented.

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U2 - 10.1021/ja0675898

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