Mechanistic studies into the Raman enhancement of enediolsemiconducting nanoparticle conjugates and their use in biological applications

Sarah J. Hurst, H. Christopher Fry, David J. Gosztola, Daniel Finkelstein-Shapiro, Vladimiro Mujica, Tijana Rajh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Raman scattering enhancement was observed in systems where different metal oxide semiconductors (TiO2, Fe2O3, ZrO 2 and CeO2) were modified with enediol ligands. The intensity of Raman scattering was dependent on laser frequency and correlated with the extinction coefficient of the charge-transfer complex of the enediol ligands and nanoparticles. The intensity and frequency of the Raman bands was found to depend on the chemical composition of the enediol ligand and the chemical composition (and crystallinity) of the nanoparticles. The intensity of the Raman signal depends on the number of surface binding sites, electron density of the ligands and their dipole moment. We also found that Raman scattering is observed for the bioconjugated system, where a peptide is linked to the surface of the particle through a catechol linker. These studies are important since these bioconjugates can be used to form the basis of Raman-based, in vitro and importantly in vivo biodetection, cell labeling and imaging, and nanotherapeutic strategies.

Original languageEnglish
Title of host publicationPhysical Chemistry of Interfaces and Nanomaterials IX
DOIs
Publication statusPublished - Oct 26 2010
EventPhysical Chemistry of Interfaces and Nanomaterials IX - San Diego, CA, United States
Duration: Aug 4 2010Aug 5 2010

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume7758
ISSN (Print)0277-786X

Other

OtherPhysical Chemistry of Interfaces and Nanomaterials IX
CountryUnited States
CitySan Diego, CA
Period8/4/108/5/10

    Fingerprint

Keywords

  • Biodiagnostics
  • Biomedical
  • Enediol
  • Nanoparticle
  • Nanotherapeutic
  • Peptide
  • Raman
  • TiO

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Hurst, S. J., Fry, H. C., Gosztola, D. J., Finkelstein-Shapiro, D., Mujica, V., & Rajh, T. (2010). Mechanistic studies into the Raman enhancement of enediolsemiconducting nanoparticle conjugates and their use in biological applications. In Physical Chemistry of Interfaces and Nanomaterials IX [77580E] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 7758). https://doi.org/10.1117/12.862931