Mechanistic studies of the rhodium-catalysed cyclization of α,ω-alkynoci acids to alkylidene lactones. Crystals structures of two iridium model catalytic intermediates

Todd B. Marder, Dominic M T Chan, William C. Fultz, Joseph C. Calabrese, David Milstein

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

A mechanism for the Rh-catalysed cyclization of alkynoic acids to alkylidene lactones which accounts for the formation of Z-isomers only, is presneted with the structures of Ir cis-hydrido-carboxylate and cis-hydrido-σ-vinyl model intermediates.

Original languageEnglish
Pages (from-to)1885-1887
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number24
DOIs
Publication statusPublished - 1987

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Iridium
Rhodium
Cyclization
Lactones
Isomers
Crystal structure
Acids

ASJC Scopus subject areas

  • Molecular Medicine

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Mechanistic studies of the rhodium-catalysed cyclization of α,ω-alkynoci acids to alkylidene lactones. Crystals structures of two iridium model catalytic intermediates. / Marder, Todd B.; Chan, Dominic M T; Fultz, William C.; Calabrese, Joseph C.; Milstein, David.

In: Journal of the Chemical Society, Chemical Communications, No. 24, 1987, p. 1885-1887.

Research output: Contribution to journalArticle

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