Abstract
We report on the endocytosis and the time-dependent enhanced cytotoxicity of anticancer platinum drugs when the drugs are combined with (or loaded into) one of the two most common types of mesoporous silica materials, MCM-41 or SBA-15. The anticancer drug cisplatin and its isomer transplatin, when loaded on MCM-41 and SBA-15 microparticles, were less cytotoxic to leukemia cells than the drugs alone after 12 h exposure. However, the drug-loaded microparticles exhibited unprecedented enhanced cytotoxicity to the cancerous cells after 24 h of exposure. This cytotoxicity of the drug-loaded microparticles was even higher than of the pure drugs in solutions, suggesting that mesoporous silica microparticles loaded with cisplatin or transplatin enabled a localized intracellular release of the platinum compounds and possibly also facilitated the drug's hydrolysis, enhancing the desired cytotoxic effect.
| Original language | English |
|---|---|
| Pages (from-to) | 789-794 |
| Number of pages | 6 |
| Journal | ACS Nano |
| Volume | 4 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 23 2010 |
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Keywords
- Adsorption capacity
- Cell viability
- Endocytosis
- Mesoporous materials
- Nanomaterials
ASJC Scopus subject areas
- Engineering(all)
- Materials Science(all)
- Physics and Astronomy(all)
Cite this
Mesoporous silica microparticles enhance the cytotoxicity of anticancer platinum drugs. / Tao, Zhimin; Toms, Bonnie; Goodisman, Jerry; Asefa, Teddy.
In: ACS Nano, Vol. 4, No. 2, 23.02.2010, p. 789-794.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mesoporous silica microparticles enhance the cytotoxicity of anticancer platinum drugs
AU - Tao, Zhimin
AU - Toms, Bonnie
AU - Goodisman, Jerry
AU - Asefa, Teddy
PY - 2010/2/23
Y1 - 2010/2/23
N2 - We report on the endocytosis and the time-dependent enhanced cytotoxicity of anticancer platinum drugs when the drugs are combined with (or loaded into) one of the two most common types of mesoporous silica materials, MCM-41 or SBA-15. The anticancer drug cisplatin and its isomer transplatin, when loaded on MCM-41 and SBA-15 microparticles, were less cytotoxic to leukemia cells than the drugs alone after 12 h exposure. However, the drug-loaded microparticles exhibited unprecedented enhanced cytotoxicity to the cancerous cells after 24 h of exposure. This cytotoxicity of the drug-loaded microparticles was even higher than of the pure drugs in solutions, suggesting that mesoporous silica microparticles loaded with cisplatin or transplatin enabled a localized intracellular release of the platinum compounds and possibly also facilitated the drug's hydrolysis, enhancing the desired cytotoxic effect.
AB - We report on the endocytosis and the time-dependent enhanced cytotoxicity of anticancer platinum drugs when the drugs are combined with (or loaded into) one of the two most common types of mesoporous silica materials, MCM-41 or SBA-15. The anticancer drug cisplatin and its isomer transplatin, when loaded on MCM-41 and SBA-15 microparticles, were less cytotoxic to leukemia cells than the drugs alone after 12 h exposure. However, the drug-loaded microparticles exhibited unprecedented enhanced cytotoxicity to the cancerous cells after 24 h of exposure. This cytotoxicity of the drug-loaded microparticles was even higher than of the pure drugs in solutions, suggesting that mesoporous silica microparticles loaded with cisplatin or transplatin enabled a localized intracellular release of the platinum compounds and possibly also facilitated the drug's hydrolysis, enhancing the desired cytotoxic effect.
KW - Adsorption capacity
KW - Cell viability
KW - Endocytosis
KW - Mesoporous materials
KW - Nanomaterials
UR - http://www.scopus.com/inward/record.url?scp=77649104780&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77649104780&partnerID=8YFLogxK
U2 - 10.1021/nn9015345
DO - 10.1021/nn9015345
M3 - Article
VL - 4
SP - 789
EP - 794
JO - ACS Nano
JF - ACS Nano
SN - 1936-0851
IS - 2
ER -