Mesoporous silica microparticles enhance the cytotoxicity of anticancer platinum drugs

Zhimin Tao, Bonnie Toms, Jerry Goodisman, Teddy Asefa

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

We report on the endocytosis and the time-dependent enhanced cytotoxicity of anticancer platinum drugs when the drugs are combined with (or loaded into) one of the two most common types of mesoporous silica materials, MCM-41 or SBA-15. The anticancer drug cisplatin and its isomer transplatin, when loaded on MCM-41 and SBA-15 microparticles, were less cytotoxic to leukemia cells than the drugs alone after 12 h exposure. However, the drug-loaded microparticles exhibited unprecedented enhanced cytotoxicity to the cancerous cells after 24 h of exposure. This cytotoxicity of the drug-loaded microparticles was even higher than of the pure drugs in solutions, suggesting that mesoporous silica microparticles loaded with cisplatin or transplatin enabled a localized intracellular release of the platinum compounds and possibly also facilitated the drug's hydrolysis, enhancing the desired cytotoxic effect.

Original languageEnglish
Pages (from-to)789-794
Number of pages6
JournalACS Nano
Volume4
Issue number2
DOIs
Publication statusPublished - Feb 23 2010

Fingerprint

microparticles
Cytotoxicity
Platinum
Silicon Dioxide
drugs
platinum
Silica
Multicarrier modulation
silicon dioxide
Platinum compounds
Pharmaceutical Preparations
Isomers
Hydrolysis
Cisplatin
platinum compounds
Platinum Compounds
leukemias
cells
hydrolysis
isomers

Keywords

  • Adsorption capacity
  • Cell viability
  • Endocytosis
  • Mesoporous materials
  • Nanomaterials

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

Cite this

Mesoporous silica microparticles enhance the cytotoxicity of anticancer platinum drugs. / Tao, Zhimin; Toms, Bonnie; Goodisman, Jerry; Asefa, Teddy.

In: ACS Nano, Vol. 4, No. 2, 23.02.2010, p. 789-794.

Research output: Contribution to journalArticle

Tao, Zhimin ; Toms, Bonnie ; Goodisman, Jerry ; Asefa, Teddy. / Mesoporous silica microparticles enhance the cytotoxicity of anticancer platinum drugs. In: ACS Nano. 2010 ; Vol. 4, No. 2. pp. 789-794.
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