Mesoporous silica microparticles enhance the cytotoxicity of anticancer platinum drugs

Zhimin Tao, Bonnie Toms, Jerry Goodisman, Tewodros Asefa

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

We report on the endocytosis and the time-dependent enhanced cytotoxicity of anticancer platinum drugs when the drugs are combined with (or loaded into) one of the two most common types of mesoporous silica materials, MCM-41 or SBA-15. The anticancer drug cisplatin and its isomer transplatin, when loaded on MCM-41 and SBA-15 microparticles, were less cytotoxic to leukemia cells than the drugs alone after 12 h exposure. However, the drug-loaded microparticles exhibited unprecedented enhanced cytotoxicity to the cancerous cells after 24 h of exposure. This cytotoxicity of the drug-loaded microparticles was even higher than of the pure drugs in solutions, suggesting that mesoporous silica microparticles loaded with cisplatin or transplatin enabled a localized intracellular release of the platinum compounds and possibly also facilitated the drug's hydrolysis, enhancing the desired cytotoxic effect.

Original languageEnglish
Pages (from-to)789-794
Number of pages6
JournalACS nano
Volume4
Issue number2
DOIs
Publication statusPublished - Feb 23 2010

    Fingerprint

Keywords

  • Adsorption capacity
  • Cell viability
  • Endocytosis
  • Mesoporous materials
  • Nanomaterials

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this