Mesoporous silica nanoparticles inhibit cellular respiration

Zhimin Tao, Matthew P. Morrow, Teddy Asefa, Krishna K. Sharma, Cole Duncan, Abhishek Anan, Harvey S. Penefsky, Jerry Goodisman, Abdul Kader Souid

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

We studied the effect of two types of mesoporous silica nanoparticles, MCM-41 and SBA-15, on mitochondrial O 2 consumption (respiration) in HL-60 (myeloid) cells, Jurkat (lymphoid) cells, and isolated mitochondria. SBA-15 inhibited cellular respiration at 25-500/ μg/mL; the inhibition was concentration-dependent and time-dependent. The cellular ATP profile paralleled that of respiration. MCM-41 had no noticeable effect on respiration rate. In cells depleted of metabolic fuels, 50 μg/mL SBA-15 delayed the onset of glucose-supported respiration by 12 min and 200 μg/mL SBA-15 by 34 min; MCM-41 also delayed the onset of glucose-supported respiration. Neither SBA-15 nor MCM-41 affected cellular glutathione. Both nanoparticles inhibited respiration of isolated mitochondria and submitochondrial particles.

Original languageEnglish
Pages (from-to)1517-1526
Number of pages10
JournalNano Letters
Volume8
Issue number5
DOIs
Publication statusPublished - May 2008

Fingerprint

respiration
Multicarrier modulation
Silicon Dioxide
Silica
Nanoparticles
silicon dioxide
nanoparticles
Mitochondria
Glucose
mitochondria
Adenosinetriphosphate
glucose
cells
Glutathione
glutathione
adenosine triphosphate
Adenosine Triphosphate
SBA-15
MCM-41
profiles

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

Cite this

Tao, Z., Morrow, M. P., Asefa, T., Sharma, K. K., Duncan, C., Anan, A., ... Souid, A. K. (2008). Mesoporous silica nanoparticles inhibit cellular respiration. Nano Letters, 8(5), 1517-1526. https://doi.org/10.1021/nl080250u

Mesoporous silica nanoparticles inhibit cellular respiration. / Tao, Zhimin; Morrow, Matthew P.; Asefa, Teddy; Sharma, Krishna K.; Duncan, Cole; Anan, Abhishek; Penefsky, Harvey S.; Goodisman, Jerry; Souid, Abdul Kader.

In: Nano Letters, Vol. 8, No. 5, 05.2008, p. 1517-1526.

Research output: Contribution to journalArticle

Tao, Z, Morrow, MP, Asefa, T, Sharma, KK, Duncan, C, Anan, A, Penefsky, HS, Goodisman, J & Souid, AK 2008, 'Mesoporous silica nanoparticles inhibit cellular respiration', Nano Letters, vol. 8, no. 5, pp. 1517-1526. https://doi.org/10.1021/nl080250u
Tao Z, Morrow MP, Asefa T, Sharma KK, Duncan C, Anan A et al. Mesoporous silica nanoparticles inhibit cellular respiration. Nano Letters. 2008 May;8(5):1517-1526. https://doi.org/10.1021/nl080250u
Tao, Zhimin ; Morrow, Matthew P. ; Asefa, Teddy ; Sharma, Krishna K. ; Duncan, Cole ; Anan, Abhishek ; Penefsky, Harvey S. ; Goodisman, Jerry ; Souid, Abdul Kader. / Mesoporous silica nanoparticles inhibit cellular respiration. In: Nano Letters. 2008 ; Vol. 8, No. 5. pp. 1517-1526.
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