Mesoporous silica nanoparticles inhibit cellular respiration

Zhimin Tao, Matthew P. Morrow, Tewodros Asefa, Krishna K. Sharma, Cole Duncan, Abhishek Anan, Harvey S. Penefsky, Jerry Goodisman, Abdul Kader Souid

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

We studied the effect of two types of mesoporous silica nanoparticles, MCM-41 and SBA-15, on mitochondrial O 2 consumption (respiration) in HL-60 (myeloid) cells, Jurkat (lymphoid) cells, and isolated mitochondria. SBA-15 inhibited cellular respiration at 25-500/ μg/mL; the inhibition was concentration-dependent and time-dependent. The cellular ATP profile paralleled that of respiration. MCM-41 had no noticeable effect on respiration rate. In cells depleted of metabolic fuels, 50 μg/mL SBA-15 delayed the onset of glucose-supported respiration by 12 min and 200 μg/mL SBA-15 by 34 min; MCM-41 also delayed the onset of glucose-supported respiration. Neither SBA-15 nor MCM-41 affected cellular glutathione. Both nanoparticles inhibited respiration of isolated mitochondria and submitochondrial particles.

Original languageEnglish
Pages (from-to)1517-1526
Number of pages10
JournalNano letters
Volume8
Issue number5
DOIs
Publication statusPublished - May 1 2008

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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  • Cite this

    Tao, Z., Morrow, M. P., Asefa, T., Sharma, K. K., Duncan, C., Anan, A., Penefsky, H. S., Goodisman, J., & Souid, A. K. (2008). Mesoporous silica nanoparticles inhibit cellular respiration. Nano letters, 8(5), 1517-1526. https://doi.org/10.1021/nl080250u