Abstract
Studies directed toward the elucidation of the structures of the metal centers in cytochrome c oxidase are reviewed. Progress towards an understanding of the interactions between these centers and their spatial distributions within the protein is also presented. The authors have employed nitric oxide (NO), as well as other exogenous ligands, to probe the O//2 reduction site of the enzyme. In addition, we have isolated auxotrophs of Saccharomyces cerevisiae in order to metabolically incorporate isotopically substituted amino acids into the yeast protein.
| Original language | English |
|---|---|
| Pages (from-to) | 43-53 |
| Number of pages | 11 |
| Journal | Chemica scripta |
| Volume | 21 |
| Issue number | 1-5 |
| Publication status | Published - 1982 |
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METAL CENTERS OF CYTOCHROME c OXIDASE : STRUCTURES AND INTERACTIONS. / Blair, David F.; Martin, Craig T.; Gelles, Jeff; Wang, Hsin; Brudvig, Gary W; Stevens, Tom H.; Chan, Sunney I.
In: Chemica scripta, Vol. 21, No. 1-5, 1982, p. 43-53.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - METAL CENTERS OF CYTOCHROME c OXIDASE
T2 - STRUCTURES AND INTERACTIONS.
AU - Blair, David F.
AU - Martin, Craig T.
AU - Gelles, Jeff
AU - Wang, Hsin
AU - Brudvig, Gary W
AU - Stevens, Tom H.
AU - Chan, Sunney I.
PY - 1982
Y1 - 1982
N2 - Studies directed toward the elucidation of the structures of the metal centers in cytochrome c oxidase are reviewed. Progress towards an understanding of the interactions between these centers and their spatial distributions within the protein is also presented. The authors have employed nitric oxide (NO), as well as other exogenous ligands, to probe the O//2 reduction site of the enzyme. In addition, we have isolated auxotrophs of Saccharomyces cerevisiae in order to metabolically incorporate isotopically substituted amino acids into the yeast protein.
AB - Studies directed toward the elucidation of the structures of the metal centers in cytochrome c oxidase are reviewed. Progress towards an understanding of the interactions between these centers and their spatial distributions within the protein is also presented. The authors have employed nitric oxide (NO), as well as other exogenous ligands, to probe the O//2 reduction site of the enzyme. In addition, we have isolated auxotrophs of Saccharomyces cerevisiae in order to metabolically incorporate isotopically substituted amino acids into the yeast protein.
UR - http://www.scopus.com/inward/record.url?scp=0020234954&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020234954&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0020234954
VL - 21
SP - 43
EP - 53
JO - Chemica scripta
JF - Chemica scripta
SN - 0004-2056
IS - 1-5
ER -