Metal-Ligand Cooperation

Julia R. Khusnutdinova, David Milstein

Research output: Contribution to journalArticle

416 Citations (Scopus)

Abstract

Metal-ligand cooperation (MLC) has become an important concept in catalysis by transition metal complexes both in synthetic and biological systems. MLC implies that both the metal and the ligand are directly involved in bond activation processes, by contrast to "classical" transition metal catalysis where the ligand (e.g. phosphine) acts as a spectator, while all key transformations occur at the metal center. In this Review, we will discuss examples of MLC in which 1) both the metal and the ligand are chemically modified during bond activation and 2) bond activation results in immediate changes in the 1st coordination sphere involving the cooperating ligand, even if the reactive center at the ligand is not directly bound to the metal (e.g. via tautomerization). The role of MLC in enabling effective catalysis as well as in catalyst deactivation reactions will be discussed. Together we're effective: Metal-ligand cooperation (MLC) implies that both the metal and the ligand are directly involved in bond activation processes, in contrast to "classical" transition metal catalysis where the ligand acts as a spectator, while all key transformations occur at the metal center. This Review discusses diverse modes of MLC in bond formation and bond cleavage reactions.

Original languageEnglish
Pages (from-to)12236-12273
Number of pages38
JournalAngewandte Chemie - International Edition
Volume54
Issue number42
DOIs
Publication statusPublished - Oct 1 2015

Fingerprint

Metals
Ligands
Catalysis
Chemical activation
Transition metals
phosphine
Catalyst deactivation
Coordination Complexes
Biological systems
Metal complexes

Keywords

  • cooperating ligands
  • homogeneous catalysis
  • metal complexes

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Metal-Ligand Cooperation. / Khusnutdinova, Julia R.; Milstein, David.

In: Angewandte Chemie - International Edition, Vol. 54, No. 42, 01.10.2015, p. 12236-12273.

Research output: Contribution to journalArticle

Khusnutdinova, Julia R. ; Milstein, David. / Metal-Ligand Cooperation. In: Angewandte Chemie - International Edition. 2015 ; Vol. 54, No. 42. pp. 12236-12273.
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