Abstract
Metal-ligand cooperation (MLC) has become an important concept in catalysis by transition metal complexes both in synthetic and biological systems. MLC implies that both the metal and the ligand are directly involved in bond activation processes, by contrast to "classical" transition metal catalysis where the ligand (e.g. phosphine) acts as a spectator, while all key transformations occur at the metal center. In this Review, we will discuss examples of MLC in which 1) both the metal and the ligand are chemically modified during bond activation and 2) bond activation results in immediate changes in the 1st coordination sphere involving the cooperating ligand, even if the reactive center at the ligand is not directly bound to the metal (e.g. via tautomerization). The role of MLC in enabling effective catalysis as well as in catalyst deactivation reactions will be discussed. Together we're effective: Metal-ligand cooperation (MLC) implies that both the metal and the ligand are directly involved in bond activation processes, in contrast to "classical" transition metal catalysis where the ligand acts as a spectator, while all key transformations occur at the metal center. This Review discusses diverse modes of MLC in bond formation and bond cleavage reactions.
| Original language | English |
|---|---|
| Pages (from-to) | 12236-12273 |
| Number of pages | 38 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 54 |
| Issue number | 42 |
| DOIs | |
| Publication status | Published - Oct 1 2015 |
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Keywords
- cooperating ligands
- homogeneous catalysis
- metal complexes
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
Cite this
Metal-Ligand Cooperation. / Khusnutdinova, Julia R.; Milstein, David.
In: Angewandte Chemie - International Edition, Vol. 54, No. 42, 01.10.2015, p. 12236-12273.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metal-Ligand Cooperation
AU - Khusnutdinova, Julia R.
AU - Milstein, David
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Metal-ligand cooperation (MLC) has become an important concept in catalysis by transition metal complexes both in synthetic and biological systems. MLC implies that both the metal and the ligand are directly involved in bond activation processes, by contrast to "classical" transition metal catalysis where the ligand (e.g. phosphine) acts as a spectator, while all key transformations occur at the metal center. In this Review, we will discuss examples of MLC in which 1) both the metal and the ligand are chemically modified during bond activation and 2) bond activation results in immediate changes in the 1st coordination sphere involving the cooperating ligand, even if the reactive center at the ligand is not directly bound to the metal (e.g. via tautomerization). The role of MLC in enabling effective catalysis as well as in catalyst deactivation reactions will be discussed. Together we're effective: Metal-ligand cooperation (MLC) implies that both the metal and the ligand are directly involved in bond activation processes, in contrast to "classical" transition metal catalysis where the ligand acts as a spectator, while all key transformations occur at the metal center. This Review discusses diverse modes of MLC in bond formation and bond cleavage reactions.
AB - Metal-ligand cooperation (MLC) has become an important concept in catalysis by transition metal complexes both in synthetic and biological systems. MLC implies that both the metal and the ligand are directly involved in bond activation processes, by contrast to "classical" transition metal catalysis where the ligand (e.g. phosphine) acts as a spectator, while all key transformations occur at the metal center. In this Review, we will discuss examples of MLC in which 1) both the metal and the ligand are chemically modified during bond activation and 2) bond activation results in immediate changes in the 1st coordination sphere involving the cooperating ligand, even if the reactive center at the ligand is not directly bound to the metal (e.g. via tautomerization). The role of MLC in enabling effective catalysis as well as in catalyst deactivation reactions will be discussed. Together we're effective: Metal-ligand cooperation (MLC) implies that both the metal and the ligand are directly involved in bond activation processes, in contrast to "classical" transition metal catalysis where the ligand acts as a spectator, while all key transformations occur at the metal center. This Review discusses diverse modes of MLC in bond formation and bond cleavage reactions.
KW - cooperating ligands
KW - homogeneous catalysis
KW - metal complexes
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U2 - 10.1002/anie.201503873
DO - 10.1002/anie.201503873
M3 - Article
VL - 54
SP - 12236
EP - 12273
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 42
ER -