Abstract
Lithographic techniques were used to develop patterned silicone rubber membranes that provide 15 μm high microchannels for artificial lungs. Two types of devices were fabricated as a proof-of-concept: one has a series of parallel, straight, open rectangular channels that are each 300 μm wide, separated by 200-μm walls, and 3-mm long and the other is a wide rectangular channel with support posts, also 3- mm long. Experiments with 30% hematocrit, venous, bovine blood showed average oxygen fluxes ranging from 11 × 10 moles/(min • cm) at a residence time of 0.04 sec to 6.5 × 10 moles/(min • cm) at a residence time of 0.20 sec. The average oxygen flux vs. residence time, which is due to transverse molecular diffusion, follows the same relation for all membranes tested. The corresponding increase in hemoglobin saturation ranged from 9% at the residence time of 0.04 sec to 24% at the residence time of 0.20 sec. The support-post channel membranes are attractive for designers because they can be arbitrarily wide and would be less prone to blockage.
| Original language | English |
|---|---|
| Pages (from-to) | 390-395 |
| Number of pages | 6 |
| Journal | ASAIO Journal |
| Volume | 54 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 2008 |
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ASJC Scopus subject areas
- Biophysics
- Biomaterials
- Bioengineering
- Biomedical Engineering
- Medicine(all)
Cite this
Microchannel technologies for artificial lungs : (3) open rectangular channels. / Lee, J. K.; Kung, M. C.; Kung, Harold H; Mockros, L. F.
In: ASAIO Journal, Vol. 54, No. 4, 07.2008, p. 390-395.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Microchannel technologies for artificial lungs
T2 - (3) open rectangular channels
AU - Lee, J. K.
AU - Kung, M. C.
AU - Kung, Harold H
AU - Mockros, L. F.
PY - 2008/7
Y1 - 2008/7
N2 - Lithographic techniques were used to develop patterned silicone rubber membranes that provide 15 μm high microchannels for artificial lungs. Two types of devices were fabricated as a proof-of-concept: one has a series of parallel, straight, open rectangular channels that are each 300 μm wide, separated by 200-μm walls, and 3-mm long and the other is a wide rectangular channel with support posts, also 3- mm long. Experiments with 30% hematocrit, venous, bovine blood showed average oxygen fluxes ranging from 11 × 10 moles/(min • cm) at a residence time of 0.04 sec to 6.5 × 10 moles/(min • cm) at a residence time of 0.20 sec. The average oxygen flux vs. residence time, which is due to transverse molecular diffusion, follows the same relation for all membranes tested. The corresponding increase in hemoglobin saturation ranged from 9% at the residence time of 0.04 sec to 24% at the residence time of 0.20 sec. The support-post channel membranes are attractive for designers because they can be arbitrarily wide and would be less prone to blockage.
AB - Lithographic techniques were used to develop patterned silicone rubber membranes that provide 15 μm high microchannels for artificial lungs. Two types of devices were fabricated as a proof-of-concept: one has a series of parallel, straight, open rectangular channels that are each 300 μm wide, separated by 200-μm walls, and 3-mm long and the other is a wide rectangular channel with support posts, also 3- mm long. Experiments with 30% hematocrit, venous, bovine blood showed average oxygen fluxes ranging from 11 × 10 moles/(min • cm) at a residence time of 0.04 sec to 6.5 × 10 moles/(min • cm) at a residence time of 0.20 sec. The average oxygen flux vs. residence time, which is due to transverse molecular diffusion, follows the same relation for all membranes tested. The corresponding increase in hemoglobin saturation ranged from 9% at the residence time of 0.04 sec to 24% at the residence time of 0.20 sec. The support-post channel membranes are attractive for designers because they can be arbitrarily wide and would be less prone to blockage.
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U2 - 10.1097/MAT.0b013e31817eda02
DO - 10.1097/MAT.0b013e31817eda02
M3 - Article
VL - 54
SP - 390
EP - 395
JO - ASAIO Journal
JF - ASAIO Journal
SN - 1058-2916
IS - 4
ER -