Microchannel technologies for artificial lungs

(3) open rectangular channels

J. K. Lee, M. C. Kung, Harold H Kung, L. F. Mockros

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Lithographic techniques were used to develop patterned silicone rubber membranes that provide 15 μm high microchannels for artificial lungs. Two types of devices were fabricated as a proof-of-concept: one has a series of parallel, straight, open rectangular channels that are each 300 μm wide, separated by 200-μm walls, and 3-mm long and the other is a wide rectangular channel with support posts, also 3- mm long. Experiments with 30% hematocrit, venous, bovine blood showed average oxygen fluxes ranging from 11 × 10 moles/(min • cm) at a residence time of 0.04 sec to 6.5 × 10 moles/(min • cm) at a residence time of 0.20 sec. The average oxygen flux vs. residence time, which is due to transverse molecular diffusion, follows the same relation for all membranes tested. The corresponding increase in hemoglobin saturation ranged from 9% at the residence time of 0.04 sec to 24% at the residence time of 0.20 sec. The support-post channel membranes are attractive for designers because they can be arbitrarily wide and would be less prone to blockage.

Original languageEnglish
Pages (from-to)390-395
Number of pages6
JournalASAIO Journal
Volume54
Issue number4
DOIs
Publication statusPublished - Jul 2008

Fingerprint

Microchannels
Oxygen
Fluxes
Technology
Membranes
Silicone Elastomers
Lung
Ion Channels
Hemoglobins
Blood
Hemoglobin
Silicones
Rubber
Hematocrit
Experiments
Equipment and Supplies

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering
  • Medicine(all)

Cite this

Microchannel technologies for artificial lungs : (3) open rectangular channels. / Lee, J. K.; Kung, M. C.; Kung, Harold H; Mockros, L. F.

In: ASAIO Journal, Vol. 54, No. 4, 07.2008, p. 390-395.

Research output: Contribution to journalArticle

Lee, J. K. ; Kung, M. C. ; Kung, Harold H ; Mockros, L. F. / Microchannel technologies for artificial lungs : (3) open rectangular channels. In: ASAIO Journal. 2008 ; Vol. 54, No. 4. pp. 390-395.
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