Abstract
(Chemical Equation Presented) Catalytic amidation of aldehydes with amines is efficiently mediated by homoleptic lanthanide amido complexes, Ln[N(SiMe 3)2]3 (Ln = La, Sm, and Y). Amidation reactivity follows the trend: La > Sm ≈ Y. These reactions proceed in high yield without added oxidants, bases, and/or heat or light, which are usually required in other catalytic amidation processes. The reaction is demonstrated with a variety of amines, with yields as high as 98% based on amine.
| Original language | English |
|---|---|
| Pages (from-to) | 317-319 |
| Number of pages | 3 |
| Journal | Organic Letters |
| Volume | 10 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 17 2008 |
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ASJC Scopus subject areas
- Molecular Medicine
Cite this
Mild amidation of aldehydes with amines mediated by lanthanide catalysts. / Seo, SungYong; Marks, Tobin J.
In: Organic Letters, Vol. 10, No. 2, 17.01.2008, p. 317-319.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mild amidation of aldehydes with amines mediated by lanthanide catalysts
AU - Seo, SungYong
AU - Marks, Tobin J
PY - 2008/1/17
Y1 - 2008/1/17
N2 - (Chemical Equation Presented) Catalytic amidation of aldehydes with amines is efficiently mediated by homoleptic lanthanide amido complexes, Ln[N(SiMe 3)2]3 (Ln = La, Sm, and Y). Amidation reactivity follows the trend: La > Sm ≈ Y. These reactions proceed in high yield without added oxidants, bases, and/or heat or light, which are usually required in other catalytic amidation processes. The reaction is demonstrated with a variety of amines, with yields as high as 98% based on amine.
AB - (Chemical Equation Presented) Catalytic amidation of aldehydes with amines is efficiently mediated by homoleptic lanthanide amido complexes, Ln[N(SiMe 3)2]3 (Ln = La, Sm, and Y). Amidation reactivity follows the trend: La > Sm ≈ Y. These reactions proceed in high yield without added oxidants, bases, and/or heat or light, which are usually required in other catalytic amidation processes. The reaction is demonstrated with a variety of amines, with yields as high as 98% based on amine.
UR - http://www.scopus.com/inward/record.url?scp=38749107636&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38749107636&partnerID=8YFLogxK
U2 - 10.1021/ol702788j
DO - 10.1021/ol702788j
M3 - Article
C2 - 18092795
AN - SCOPUS:38749107636
VL - 10
SP - 317
EP - 319
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 2
ER -