Abstract
(Chemical Equation Presented) Catalytic amidation of aldehydes with amines is efficiently mediated by homoleptic lanthanide amido complexes, Ln[N(SiMe 3)2]3 (Ln = La, Sm, and Y). Amidation reactivity follows the trend: La > Sm ≈ Y. These reactions proceed in high yield without added oxidants, bases, and/or heat or light, which are usually required in other catalytic amidation processes. The reaction is demonstrated with a variety of amines, with yields as high as 98% based on amine.
| Original language | English |
|---|---|
| Pages (from-to) | 317-319 |
| Number of pages | 3 |
| Journal | Organic Letters |
| Volume | 10 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 17 2008 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Seo, S. Y., & Marks, T. J. (2008). Mild amidation of aldehydes with amines mediated by lanthanide catalysts. Organic Letters, 10(2), 317-319. https://doi.org/10.1021/ol702788j