Mild amidation of aldehydes with amines mediated by lanthanide catalysts

SungYong Seo, Tobin J Marks

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

(Chemical Equation Presented) Catalytic amidation of aldehydes with amines is efficiently mediated by homoleptic lanthanide amido complexes, Ln[N(SiMe 3)2]3 (Ln = La, Sm, and Y). Amidation reactivity follows the trend: La > Sm ≈ Y. These reactions proceed in high yield without added oxidants, bases, and/or heat or light, which are usually required in other catalytic amidation processes. The reaction is demonstrated with a variety of amines, with yields as high as 98% based on amine.

Original languageEnglish
Pages (from-to)317-319
Number of pages3
JournalOrganic Letters
Volume10
Issue number2
DOIs
Publication statusPublished - Jan 17 2008

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Lanthanoid Series Elements
aldehydes
Aldehydes
Amines
amines
catalysts
Catalysts
Oxidants
reactivity
Hot Temperature
trends
Light
heat

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Mild amidation of aldehydes with amines mediated by lanthanide catalysts. / Seo, SungYong; Marks, Tobin J.

In: Organic Letters, Vol. 10, No. 2, 17.01.2008, p. 317-319.

Research output: Contribution to journalArticle

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