Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung

Matthew C. Duch, G. R Scott Budinger, Yu Teng Liang, Saul Soberanes, Daniela Urich, Sergio E. Chiarella, Laura A. Campochiaro, Angel Gonzalez, Navdeep S. Chandel, Mark C Hersam, Gökhan M. Mutlu

Research output: Contribution to journalArticle

326 Citations (Scopus)

Abstract

To facilitate the proposed use of graphene and its derivative graphene oxide (GO) in widespread applications, we explored strategies that improve the biocompatibility of graphene nanomaterials in the lung. In particular, solutions of aggregated graphene, Pluronic dispersed graphene, and GO were administered directly into the lungs of mice. The introduction of GO resulted in severe and persistent lung injury. Furthermore, in cells GO increased the rate of mitochondrial respiration and the generation of reactive oxygen species, activating inflammatory and apoptotic pathways. In contrast, this toxicity was significantly reduced in the case of pristine graphene after liquid phase exfoliation and was further minimized when the unoxidized graphene was well-dispersed with the block copolymer Pluronic. Our results demonstrate that the covalent oxidation of graphene is a major contributor to its pulmonary toxicity and suggest that dispersion of pristine graphene in Pluronic provides a pathway for the safe handling and potential biomedical application of two-dimensional carbon nanomaterials.

Original languageEnglish
Pages (from-to)5201-5207
Number of pages7
JournalNano Letters
Volume11
Issue number12
DOIs
Publication statusPublished - Dec 14 2011

Fingerprint

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biocompatibility
Biocompatibility
lungs
Graphene
graphene
Oxidation
oxidation
Poloxamer
Oxides
oxides
Nanostructured materials
toxicity
Toxicity
Safe handling
respiration
block copolymers
Block copolymers
mice
Reactive Oxygen Species

Keywords

  • biocompatibility
  • Graphene
  • graphene oxide
  • pluronic
  • poloxamer

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

Cite this

Duch, M. C., Budinger, G. R. S., Liang, Y. T., Soberanes, S., Urich, D., Chiarella, S. E., ... Mutlu, G. M. (2011). Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung. Nano Letters, 11(12), 5201-5207. https://doi.org/10.1021/nl202515a

Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung. / Duch, Matthew C.; Budinger, G. R Scott; Liang, Yu Teng; Soberanes, Saul; Urich, Daniela; Chiarella, Sergio E.; Campochiaro, Laura A.; Gonzalez, Angel; Chandel, Navdeep S.; Hersam, Mark C; Mutlu, Gökhan M.

In: Nano Letters, Vol. 11, No. 12, 14.12.2011, p. 5201-5207.

Research output: Contribution to journalArticle

Duch, MC, Budinger, GRS, Liang, YT, Soberanes, S, Urich, D, Chiarella, SE, Campochiaro, LA, Gonzalez, A, Chandel, NS, Hersam, MC & Mutlu, GM 2011, 'Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung', Nano Letters, vol. 11, no. 12, pp. 5201-5207. https://doi.org/10.1021/nl202515a
Duch MC, Budinger GRS, Liang YT, Soberanes S, Urich D, Chiarella SE et al. Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung. Nano Letters. 2011 Dec 14;11(12):5201-5207. https://doi.org/10.1021/nl202515a
Duch, Matthew C. ; Budinger, G. R Scott ; Liang, Yu Teng ; Soberanes, Saul ; Urich, Daniela ; Chiarella, Sergio E. ; Campochiaro, Laura A. ; Gonzalez, Angel ; Chandel, Navdeep S. ; Hersam, Mark C ; Mutlu, Gökhan M. / Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung. In: Nano Letters. 2011 ; Vol. 11, No. 12. pp. 5201-5207.
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