Mirror image DNA nanostructures for chiral supramolecular assemblies

Chenxiang Lin, Yonggang Ke, Zhe Li, James H. Wang, Yan Liu, Hao Yan

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

L-DNA, the mirror image of natural D-DNA, can be readily self-assembled into designer discrete or periodic nanostructures. The assembly products are characterized by polyacrylamide gel electrophoresis, circular dichroism spectrum, atomic force microscope, and fluorescence microscope. We found that the use of enantiomer DNA as building material leads to the formation of DNA supramolecules with opposite chirality. Therefore, the L-DNA self-assembly is a substantial complement to the structural DNA nanotechnology. Moreover, the L-DNA architectures feature superior nuclease resistance thus are appealing for in vivo medical applications.

Original languageEnglish
Pages (from-to)433-436
Number of pages4
JournalNano Letters
Volume9
Issue number1
DOIs
Publication statusPublished - Jan 2009

Fingerprint

assemblies
Nanostructures
Mirrors
DNA
deoxyribonucleic acid
mirrors
Microscopes
microscopes
nuclease
atomic spectra
Enantiomers
Chirality
enantiomers
Dichroism
Medical applications
electrophoresis
nanotechnology
Polyacrylates
Electrophoresis
Nanotechnology

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

Cite this

Mirror image DNA nanostructures for chiral supramolecular assemblies. / Lin, Chenxiang; Ke, Yonggang; Li, Zhe; Wang, James H.; Liu, Yan; Yan, Hao.

In: Nano Letters, Vol. 9, No. 1, 01.2009, p. 433-436.

Research output: Contribution to journalArticle

Lin, Chenxiang ; Ke, Yonggang ; Li, Zhe ; Wang, James H. ; Liu, Yan ; Yan, Hao. / Mirror image DNA nanostructures for chiral supramolecular assemblies. In: Nano Letters. 2009 ; Vol. 9, No. 1. pp. 433-436.
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