Modification of fibrous poly(L-lactic acid) scaffolds with self-assembling triblock molecules

John C. Stendahl, Leiming Li, Randal C. Claussen, Samuel I Stupp

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Molecular self-assembly offers an effective method to modify the surface properties of common biomaterials by presenting biologically relevant chemistry in a controlled, ordered fashion. This work reports on self-assembling triblock molecules containing rigid cholesteryl segments followed by flexible oligomers of L-(lactic acid) and second generation L-lysine dendrons. Second harmonic generation and small angle X-ray scattering indicate these molecules self-assemble into multilayer polar structures when cast from ethyl acetate solutions and segregate into polar polydomains when annealed. These self-assembled layers significantly improve water wettability when coated onto poly(L-lactic acid) fibers. Scaffolds formed from fibers modified by self-assembly enhance adhesion of 3T3 mouse calvaria cells and produce greater population growth rates. These results demonstrate the use of self-assembly to present biologically relevant chemistry on surfaces of biomaterials. Applications of this technology include the modification of substrates for cell culture, tissue engineering, and cell transplantation.

Original languageEnglish
Pages (from-to)5847-5856
Number of pages10
JournalBiomaterials
Volume25
Issue number27
DOIs
Publication statusPublished - Dec 2004

Fingerprint

Biocompatible Materials
Lactic acid
Scaffolds
Self assembly
Wettability
Dendrimers
Biomaterials
Tissue Transplantation
Molecules
Surface Properties
Population Growth
Cell Transplantation
Tissue Engineering
Skull
Self Report
Transplantation (surgical)
Lysine
Lactic Acid
Tissue culture
Fibers

Keywords

  • Cell adhesion
  • Polylactic acid
  • Scaffold
  • Self-assembly
  • Surface modification

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Modification of fibrous poly(L-lactic acid) scaffolds with self-assembling triblock molecules. / Stendahl, John C.; Li, Leiming; Claussen, Randal C.; Stupp, Samuel I.

In: Biomaterials, Vol. 25, No. 27, 12.2004, p. 5847-5856.

Research output: Contribution to journalArticle

Stendahl, John C. ; Li, Leiming ; Claussen, Randal C. ; Stupp, Samuel I. / Modification of fibrous poly(L-lactic acid) scaffolds with self-assembling triblock molecules. In: Biomaterials. 2004 ; Vol. 25, No. 27. pp. 5847-5856.
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