Abstract
Molecular self-assembly offers an effective method to modify the surface properties of common biomaterials by presenting biologically relevant chemistry in a controlled, ordered fashion. This work reports on self-assembling triblock molecules containing rigid cholesteryl segments followed by flexible oligomers of L-(lactic acid) and second generation L-lysine dendrons. Second harmonic generation and small angle X-ray scattering indicate these molecules self-assemble into multilayer polar structures when cast from ethyl acetate solutions and segregate into polar polydomains when annealed. These self-assembled layers significantly improve water wettability when coated onto poly(L-lactic acid) fibers. Scaffolds formed from fibers modified by self-assembly enhance adhesion of 3T3 mouse calvaria cells and produce greater population growth rates. These results demonstrate the use of self-assembly to present biologically relevant chemistry on surfaces of biomaterials. Applications of this technology include the modification of substrates for cell culture, tissue engineering, and cell transplantation.
| Original language | English |
|---|---|
| Pages (from-to) | 5847-5856 |
| Number of pages | 10 |
| Journal | Biomaterials |
| Volume | 25 |
| Issue number | 27 |
| DOIs | |
| Publication status | Published - Dec 2004 |
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Keywords
- Cell adhesion
- Polylactic acid
- Scaffold
- Self-assembly
- Surface modification
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering
Cite this
Modification of fibrous poly(L-lactic acid) scaffolds with self-assembling triblock molecules. / Stendahl, John C.; Li, Leiming; Claussen, Randal C.; Stupp, Samuel I.
In: Biomaterials, Vol. 25, No. 27, 12.2004, p. 5847-5856.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Modification of fibrous poly(L-lactic acid) scaffolds with self-assembling triblock molecules
AU - Stendahl, John C.
AU - Li, Leiming
AU - Claussen, Randal C.
AU - Stupp, Samuel I
PY - 2004/12
Y1 - 2004/12
N2 - Molecular self-assembly offers an effective method to modify the surface properties of common biomaterials by presenting biologically relevant chemistry in a controlled, ordered fashion. This work reports on self-assembling triblock molecules containing rigid cholesteryl segments followed by flexible oligomers of L-(lactic acid) and second generation L-lysine dendrons. Second harmonic generation and small angle X-ray scattering indicate these molecules self-assemble into multilayer polar structures when cast from ethyl acetate solutions and segregate into polar polydomains when annealed. These self-assembled layers significantly improve water wettability when coated onto poly(L-lactic acid) fibers. Scaffolds formed from fibers modified by self-assembly enhance adhesion of 3T3 mouse calvaria cells and produce greater population growth rates. These results demonstrate the use of self-assembly to present biologically relevant chemistry on surfaces of biomaterials. Applications of this technology include the modification of substrates for cell culture, tissue engineering, and cell transplantation.
AB - Molecular self-assembly offers an effective method to modify the surface properties of common biomaterials by presenting biologically relevant chemistry in a controlled, ordered fashion. This work reports on self-assembling triblock molecules containing rigid cholesteryl segments followed by flexible oligomers of L-(lactic acid) and second generation L-lysine dendrons. Second harmonic generation and small angle X-ray scattering indicate these molecules self-assemble into multilayer polar structures when cast from ethyl acetate solutions and segregate into polar polydomains when annealed. These self-assembled layers significantly improve water wettability when coated onto poly(L-lactic acid) fibers. Scaffolds formed from fibers modified by self-assembly enhance adhesion of 3T3 mouse calvaria cells and produce greater population growth rates. These results demonstrate the use of self-assembly to present biologically relevant chemistry on surfaces of biomaterials. Applications of this technology include the modification of substrates for cell culture, tissue engineering, and cell transplantation.
KW - Cell adhesion
KW - Polylactic acid
KW - Scaffold
KW - Self-assembly
KW - Surface modification
UR - http://www.scopus.com/inward/record.url?scp=2542498641&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2542498641&partnerID=8YFLogxK
U2 - 10.1016/j.biomaterials.2004.01.042
DO - 10.1016/j.biomaterials.2004.01.042
M3 - Article
VL - 25
SP - 5847
EP - 5856
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 27
ER -