Modular self-assembly of DNA lattices with tunable periodicity

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A modular self-assembly for constructing periodic DNA lattices with tunable periodic cavity sizes that is important for the implementation of DNA-lattice formation. The rhombus-like DNA tile was modified by providing it into modules where the tile modules contain four four-arm junctions. The four tile module define the directionality of the lattice dimension while the linker modules define the cavity size of the lattice. The key advantage of the modular assembly is that one can keep the structure and sequence composition of the tile modules unchanged while only changing the length of the linker modules to achieve tunable periodicity of the lattice. The design is useful when large-size DNA tiles are required for lattice assembly where the modular design will avoid the necessity to resynthesize the long DNA oligomers required for direct assembly of full rhombus-like tiles. It is possible to achieve scalable DNS-based nanoconstructions using the modular self-assembly technique.

Original languageEnglish
Pages (from-to)327-330
Number of pages4
JournalSmall
Volume1
Issue number3
DOIs
Publication statusPublished - Mar 2005

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Periodicity
Tile
Self assembly
DNA
Oligomers
Chemical analysis

Keywords

  • Atomic force microscopy
  • DNA
  • Nanostructures
  • Self-assembly

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology
  • Medicine(all)

Cite this

Modular self-assembly of DNA lattices with tunable periodicity. / Liu, Yan; Yan, Hao.

In: Small, Vol. 1, No. 3, 03.2005, p. 327-330.

Research output: Contribution to journalArticle

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