N-H activation of amines and ammonia by Ru via metal-ligand cooperation

Eugene Khaskin, Mark A. Iron, Linda J.W. Shimon, Jing Zhang, David Milstein

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

A nonoxidative addition pathway for the activation of NH bonds of ammonia and amines by a Ru(II) complex is reported. The pincer complex 1 cleaves N-H bonds via metal-ligand cooperation involving aromatization of the pincer ligand without a change in the formal oxidation state of the metal. Electron-rich N-H bond substrates lead to reversible activation, while electron-poor substrates result in stable activation products. Isotopic labeling studies using ND 3 as well as density functional theory calculations were used to shed light on the N-H activation mechanism.

Original languageEnglish
Pages (from-to)8542-8543
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number25
DOIs
Publication statusPublished - Jun 30 2010

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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