N-H activation of amines and ammonia by Ru via metal-ligand cooperation

Eugene Khaskin, Mark A. Iron, Linda J W Shimon, Jing Zhang, David Milstein

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

A nonoxidative addition pathway for the activation of NH bonds of ammonia and amines by a Ru(II) complex is reported. The pincer complex 1 cleaves N-H bonds via metal-ligand cooperation involving aromatization of the pincer ligand without a change in the formal oxidation state of the metal. Electron-rich N-H bond substrates lead to reversible activation, while electron-poor substrates result in stable activation products. Isotopic labeling studies using ND 3 as well as density functional theory calculations were used to shed light on the N-H activation mechanism.

Original languageEnglish
Pages (from-to)8542-8543
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number25
DOIs
Publication statusPublished - Jun 30 2010

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Ammonia
Amines
Metals
Chemical activation
Ligands
Electrons
Aromatization
Substrates
Labeling
Density functional theory
Oxidation

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

N-H activation of amines and ammonia by Ru via metal-ligand cooperation. / Khaskin, Eugene; Iron, Mark A.; Shimon, Linda J W; Zhang, Jing; Milstein, David.

In: Journal of the American Chemical Society, Vol. 132, No. 25, 30.06.2010, p. 8542-8543.

Research output: Contribution to journalArticle

Khaskin, Eugene ; Iron, Mark A. ; Shimon, Linda J W ; Zhang, Jing ; Milstein, David. / N-H activation of amines and ammonia by Ru via metal-ligand cooperation. In: Journal of the American Chemical Society. 2010 ; Vol. 132, No. 25. pp. 8542-8543.
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