Nanopatterned substrates increase surface sensitivity for real-time biosensing

Julia Y. Lin, Andreea D. Stuparu, Mark D. Huntington, Milan Mrksich, Teri W. Odom

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


In this paper, we report critical design rules for improving the sensitivity of plasmonic biosensors. We use a scalable, parallel method to fabricate Au plasmonic crystal substrates patterned with an array of pits for real-time sensing. Capture ligands printed selectively in these pits resulted in a strong response to the binding of macromolecules. Angle-resolved sensorgrams showed quantitative differences between wavelength shifts produced by protein analyte bound within regions supporting localized and long-range electromagnetic fields. Contributions from the localized fields dominated the sensing response, especially at high angles. The angle-dependent far-field and near-field optical properties of selectively functionalized plasmonic crystals suggest that optimal performance is achieved at excitation parameters that produce an intense resonance with narrow spectral bandwidth and highly localized electromagnetic fields.

Original languageEnglish
Pages (from-to)5286-5292
Number of pages7
JournalJournal of Physical Chemistry C
Issue number10
Publication statusPublished - Mar 14 2013

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Energy(all)
  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films

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