Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis

Peng Li, Su Young Moon, Mark A. Guelta, Lu Lin, Diego A. Gómez-Gualdrón, Randall Q. Snurr, Steven P. Harvey, Joseph T Hupp, Omar K. Farha

Research output: Contribution to journal › Article

67 Citations (Scopus)

Abstract

We report the synthesis and characterization of a water-stable zirconium metal-organic framework (MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.

Original languageEnglish
Pages (from-to)9174-9182
Number of pages9
JournalACS Nano
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 25 2016

Fingerprint

Aryldialkylphosphatase
nerves
hydrolysis
enzymes
Hydrolysis
Enzymes
Metals
acids
Acids
Zirconium
metals
apertures
Nerve Agents
Water
synthesis
water

Keywords

  • enzyme immobilization
  • metal-organic framework
  • nanocarrier
  • nerve agent catalysis

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Li, P., Moon, S. Y., Guelta, M. A., Lin, L., Gómez-Gualdrón, D. A., Snurr, R. Q., ... Farha, O. K. (2016). Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis. ACS Nano, 10(10), 9174-9182. https://doi.org/10.1021/acsnano.6b04996

Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis. / Li, Peng; Moon, Su Young; Guelta, Mark A.; Lin, Lu; Gómez-Gualdrón, Diego A.; Snurr, Randall Q.; Harvey, Steven P.; Hupp, Joseph T; Farha, Omar K.

In: ACS Nano, Vol. 10, No. 10, 25.10.2016, p. 9174-9182.

Research output: Contribution to journal › Article

Li, P, Moon, SY, Guelta, MA, Lin, L, Gómez-Gualdrón, DA, Snurr, RQ, Harvey, SP, Hupp, JT & Farha, OK 2016, 'Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis', ACS Nano, vol. 10, no. 10, pp. 9174-9182. https://doi.org/10.1021/acsnano.6b04996
Li P, Moon SY, Guelta MA, Lin L, Gómez-Gualdrón DA, Snurr RQ et al. Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis. ACS Nano. 2016 Oct 25;10(10):9174-9182. https://doi.org/10.1021/acsnano.6b04996
Li, Peng ; Moon, Su Young ; Guelta, Mark A. ; Lin, Lu ; Gómez-Gualdrón, Diego A. ; Snurr, Randall Q. ; Harvey, Steven P. ; Hupp, Joseph T ; Farha, Omar K. / Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis. In: ACS Nano. 2016 ; Vol. 10, No. 10. pp. 9174-9182.
@article{d17e8e9c75304a2896aa58d0aaaa012f,
title = "Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis",
abstract = "We report the synthesis and characterization of a water-stable zirconium metal-organic framework (MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.",
keywords = "enzyme immobilization, metal-organic framework, nanocarrier, nerve agent catalysis",
author = "Peng Li and Moon, {Su Young} and Guelta, {Mark A.} and Lu Lin and G{\'o}mez-Gualdr{\'o}n, {Diego A.} and Snurr, {Randall Q.} and Harvey, {Steven P.} and Hupp, {Joseph T} and Farha, {Omar K.}",
year = "2016",
month = "10",
day = "25",
doi = "10.1021/acsnano.6b04996",
language = "English",
volume = "10",
pages = "9174--9182",
journal = "ACS Nano",
issn = "1936-0851",
publisher = "American Chemical Society",
number = "10",

}

TY - JOUR

T1 - Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis

AU - Li, Peng

AU - Moon, Su Young

AU - Guelta, Mark A.

AU - Lin, Lu

AU - Gómez-Gualdrón, Diego A.

AU - Snurr, Randall Q.

AU - Harvey, Steven P.

AU - Hupp, Joseph T

AU - Farha, Omar K.

PY - 2016/10/25

Y1 - 2016/10/25

N2 - We report the synthesis and characterization of a water-stable zirconium metal-organic framework (MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.

AB - We report the synthesis and characterization of a water-stable zirconium metal-organic framework (MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.

KW - enzyme immobilization

KW - metal-organic framework

KW - nanocarrier

KW - nerve agent catalysis

UR - http://www.scopus.com/inward/record.url?scp=84994009770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994009770&partnerID=8YFLogxK

U2 - 10.1021/acsnano.6b04996

DO - 10.1021/acsnano.6b04996

M3 - Article

AN - SCOPUS:84994009770

VL - 10

SP - 9174

EP - 9182

JO - ACS Nano

JF - ACS Nano

SN - 1936-0851

IS - 10

ER -

Access to Document