@article{d17e8e9c75304a2896aa58d0aaaa012f,
title = "Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis",
abstract = "We report the synthesis and characterization of a water-stable zirconium metal-organic framework (MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.",
keywords = "enzyme immobilization, metal-organic framework, nanocarrier, nerve agent catalysis",
author = "Peng Li and Moon, {Su Young} and Guelta, {Mark A.} and Lu Lin and G{\'o}mez-Gualdr{\'o}n, {Diego A.} and Snurr, {Randall Q.} and Harvey, {Steven P.} and Hupp, {Joseph T.} and Farha, {Omar K.}",
note = "Funding Information: O.K.F., J.T.H., and R.Q.S. gratefully acknowledge DTRA for financial support (Grant No. HDTRA-1-14-1-0014). This work made use of the J.B. Cohen X-ray Diffraction Facility supported by the MRSEC program of the National Science Foundation (DMR-1121262) at the Materials Research Center of North-western University. Confocal microscopy imaging work was done at the Northwestern University Biological Imaging Facility generously supported by the NU Office for Research.This work also made use of the EPIC facility (NUANCE Center, Northwestern University), which has received support from the MRSEC program (NSF DMR-1121262) at the Materials Research Center; the International Institute for Nanotechnology (IIN); and the State of Illinois, through the IIN. Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",
year = "2016",
month = oct,
day = "25",
doi = "10.1021/acsnano.6b04996",
language = "English",
volume = "10",
pages = "9174--9182",
journal = "ACS Nano",
issn = "1936-0851",
publisher = "American Chemical Society",
number = "10",
}