Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis

Peng Li; Su Young Moon; Mark A. Guelta; Lu Lin; Diego A. Gómez-Gualdrón; Randall Q. Snurr; Steven P. Harvey; Joseph T. Hupp; Omar K. Farha

doi:10.1021/acsnano.6b04996

Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis

Peng Li, Su Young Moon, Mark A. Guelta, Lu Lin, Diego A. Gómez-Gualdrón, Randall Q. Snurr, Steven P. Harvey, Joseph T. Hupp, Omar K. Farha

Northwestern University

Research output: Contribution to journal › Article

88 Citations (Scopus)

Abstract

We report the synthesis and characterization of a water-stable zirconium metal-organic framework (MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.

Original language	English
Pages (from-to)	9174-9182
Number of pages	9
Journal	ACS nano
Volume	10
Issue number	10
DOIs	https://doi.org/10.1021/acsnano.6b04996
Publication status	Published - Oct 25 2016

Keywords

enzyme immobilization
metal-organic framework
nanocarrier
nerve agent catalysis

ASJC Scopus subject areas

Materials Science(all)
Engineering(all)
Physics and Astronomy(all)

Access to Document

10.1021/acsnano.6b04996

Fingerprint Dive into the research topics of 'Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis'. Together they form a unique fingerprint.

Cite this

Li, P., Moon, S. Y., Guelta, M. A., Lin, L., Gómez-Gualdrón, D. A., Snurr, R. Q., Harvey, S. P., Hupp, J. T., & Farha, O. K. (2016). Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis. ACS nano, 10(10), 9174-9182. https://doi.org/10.1021/acsnano.6b04996

@article{d17e8e9c75304a2896aa58d0aaaa012f,

title = "Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis",

abstract = "We report the synthesis and characterization of a water-stable zirconium metal-organic framework (MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.",

keywords = "enzyme immobilization, metal-organic framework, nanocarrier, nerve agent catalysis",

author = "Peng Li and Moon, {Su Young} and Guelta, {Mark A.} and Lu Lin and G{\'o}mez-Gualdr{\'o}n, {Diego A.} and Snurr, {Randall Q.} and Harvey, {Steven P.} and Hupp, {Joseph T.} and Farha, {Omar K.}",

year = "2016",

month = oct,

day = "25",

doi = "10.1021/acsnano.6b04996",

language = "English",

volume = "10",

pages = "9174--9182",

journal = "ACS Nano",

issn = "1936-0851",

publisher = "American Chemical Society",

number = "10",

}

TY - JOUR

T1 - Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis

AU - Li, Peng

AU - Moon, Su Young

AU - Guelta, Mark A.

AU - Lin, Lu

AU - Gómez-Gualdrón, Diego A.

AU - Snurr, Randall Q.

AU - Harvey, Steven P.

AU - Hupp, Joseph T.

AU - Farha, Omar K.

PY - 2016/10/25

Y1 - 2016/10/25

N2 - We report the synthesis and characterization of a water-stable zirconium metal-organic framework (MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.

AB - We report the synthesis and characterization of a water-stable zirconium metal-organic framework (MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers.

KW - enzyme immobilization

KW - metal-organic framework

KW - nanocarrier

KW - nerve agent catalysis

UR - http://www.scopus.com/inward/record.url?scp=84994009770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994009770&partnerID=8YFLogxK

U2 - 10.1021/acsnano.6b04996

DO - 10.1021/acsnano.6b04996

M3 - Article

AN - SCOPUS:84994009770

VL - 10

SP - 9174

EP - 9182

JO - ACS Nano

JF - ACS Nano

SN - 1936-0851

IS - 10

ER -