Non-blinking 'Giant' nanocrystal quantum dots: Ideal probes for real-time three-dimensional tracking

Jennifer A. Hollingsworth, James H. Werner, Han Htoon, Andrei Piryatinski, Richard Schaller, Yagnaseni Ghosh, Allison M. Dennis, Aaron M. Keller, Benjamin Mangum, Daniel C. Hannah

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe the development and characterization of two novel non-blinking 'giant' nanocrystal quantum dot (g-NQD) systems and their application to single-particle tracking in live cells real-time and in three dimensions. The two g-NQDs - CdSe/CdS and InP/CdS - are characterized by a thick shell layer (>10 monolayers of CdS), a quasi-type-II or type-II electronic structure, and extremely suppressed non-radiative Auger recombination and photobleaching, in addition to suppressed blinking. We show that these unique traits make this new class of NQD ideal molecular probes for observing spatio-temporal dynamics of cellular processes.

Original languageEnglish
Title of host publication2013 Conference on Lasers and Electro-Optics, CLEO 2013
PublisherIEEE Computer Society
ISBN (Print)9781557529725
Publication statusPublished - Jan 1 2013
Event2013 Conference on Lasers and Electro-Optics, CLEO 2013 - San Jose, CA, United States
Duration: Jun 9 2013Jun 14 2013

Publication series

Name2013 Conference on Lasers and Electro-Optics, CLEO 2013

Other

Other2013 Conference on Lasers and Electro-Optics, CLEO 2013
CountryUnited States
CitySan Jose, CA
Period6/9/136/14/13

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials

Cite this

Hollingsworth, J. A., Werner, J. H., Htoon, H., Piryatinski, A., Schaller, R., Ghosh, Y., Dennis, A. M., Keller, A. M., Mangum, B., & Hannah, D. C. (2013). Non-blinking 'Giant' nanocrystal quantum dots: Ideal probes for real-time three-dimensional tracking. In 2013 Conference on Lasers and Electro-Optics, CLEO 2013 [6834475] (2013 Conference on Lasers and Electro-Optics, CLEO 2013). IEEE Computer Society.