Abstract
We describe the development and characterization of two novel non-blinking 'giant' nanocrystal quantum dot (g-NQD) systems and their application to single-particle tracking in live cells real-time and in three dimensions. The two g-NQDs - CdSe/CdS and InP/CdS - are characterized by a thick shell layer (>10 monolayers of CdS), a quasi-type-II or type-II electronic structure, and extremely suppressed non-radiative Auger recombination and photobleaching, in addition to suppressed blinking. We show that these unique traits make this new class of NQD ideal molecular probes for observing spatio-temporal dynamics of cellular processes.
| Original language | English |
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| Title of host publication | 2013 Conference on Lasers and Electro-Optics, CLEO 2013 |
| Publisher | IEEE Computer Society |
| ISBN (Print) | 9781557529725 |
| Publication status | Published - Jan 1 2013 |
| Event | 2013 Conference on Lasers and Electro-Optics, CLEO 2013 - San Jose, CA, United States Duration: Jun 9 2013 → Jun 14 2013 |
Publication series
| Name | 2013 Conference on Lasers and Electro-Optics, CLEO 2013 |
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Other
| Other | 2013 Conference on Lasers and Electro-Optics, CLEO 2013 |
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| Country | United States |
| City | San Jose, CA |
| Period | 6/9/13 → 6/14/13 |
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ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
Cite this
Hollingsworth, J. A., Werner, J. H., Htoon, H., Piryatinski, A., Schaller, R., Ghosh, Y., Dennis, A. M., Keller, A. M., Mangum, B., & Hannah, D. C. (2013). Non-blinking 'Giant' nanocrystal quantum dots: Ideal probes for real-time three-dimensional tracking. In 2013 Conference on Lasers and Electro-Optics, CLEO 2013 [6834475] (2013 Conference on Lasers and Electro-Optics, CLEO 2013). IEEE Computer Society.