Non-blinking "Giant" nanocrystal quantum dots: Ideal probes for real-time three-dimensional tracking

Jennifer A. Hollingsworth, James H. Werner, Han Htoon, Andrei Piryatinski, Richard D Schaller, Yagnaseni Ghosh, Allison M. Dennis, Aaron M. Keller, Benjamin Mangum, Daniel C. Hannah

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We describe the development and characterization of two novel non-blinking "giant" nanocrystal quantum dot (g-NQD) systems and their application to single-particle tracking in live cells real-time and in three dimensions. The two g-NQDs - CdSe/CdS and InP/CdS - are characterized by a thick shell layer (>10 monolayers of CdS), a quasi-type-II or type-II electronic structure, and extremely suppressed non-radiative Auger recombination and photobleaching, in addition to suppressed blinking. We show that these unique traits make this new class of NQD ideal molecular probes for observing spatio-temporal dynamics of cellular processes.

Original languageEnglish
Title of host publicationCLEO: QELS_Fundamental Science, CLEO:QELS FS 2013
Publication statusPublished - 2013
EventCLEO: QELS_Fundamental Science, CLEO:QELS FS 2013 - San Jose, CA, United States
Duration: Jun 9 2013Jun 14 2013

Other

OtherCLEO: QELS_Fundamental Science, CLEO:QELS FS 2013
CountryUnited States
CitySan Jose, CA
Period6/9/136/14/13

Fingerprint

blinking
Molecular Probes
Photobleaching
Nanocrystals
Semiconductor quantum dots
Electronic structure
Monolayers
nanocrystals
quantum dots
electronic structure
probes
cells

ASJC Scopus subject areas

  • Computer Networks and Communications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Hollingsworth, J. A., Werner, J. H., Htoon, H., Piryatinski, A., Schaller, R. D., Ghosh, Y., ... Hannah, D. C. (2013). Non-blinking "Giant" nanocrystal quantum dots: Ideal probes for real-time three-dimensional tracking. In CLEO: QELS_Fundamental Science, CLEO:QELS FS 2013

Non-blinking "Giant" nanocrystal quantum dots : Ideal probes for real-time three-dimensional tracking. / Hollingsworth, Jennifer A.; Werner, James H.; Htoon, Han; Piryatinski, Andrei; Schaller, Richard D; Ghosh, Yagnaseni; Dennis, Allison M.; Keller, Aaron M.; Mangum, Benjamin; Hannah, Daniel C.

CLEO: QELS_Fundamental Science, CLEO:QELS FS 2013. 2013.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hollingsworth, JA, Werner, JH, Htoon, H, Piryatinski, A, Schaller, RD, Ghosh, Y, Dennis, AM, Keller, AM, Mangum, B & Hannah, DC 2013, Non-blinking "Giant" nanocrystal quantum dots: Ideal probes for real-time three-dimensional tracking. in CLEO: QELS_Fundamental Science, CLEO:QELS FS 2013. CLEO: QELS_Fundamental Science, CLEO:QELS FS 2013, San Jose, CA, United States, 6/9/13.
Hollingsworth JA, Werner JH, Htoon H, Piryatinski A, Schaller RD, Ghosh Y et al. Non-blinking "Giant" nanocrystal quantum dots: Ideal probes for real-time three-dimensional tracking. In CLEO: QELS_Fundamental Science, CLEO:QELS FS 2013. 2013
Hollingsworth, Jennifer A. ; Werner, James H. ; Htoon, Han ; Piryatinski, Andrei ; Schaller, Richard D ; Ghosh, Yagnaseni ; Dennis, Allison M. ; Keller, Aaron M. ; Mangum, Benjamin ; Hannah, Daniel C. / Non-blinking "Giant" nanocrystal quantum dots : Ideal probes for real-time three-dimensional tracking. CLEO: QELS_Fundamental Science, CLEO:QELS FS 2013. 2013.
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