One-Pot Hydrothermal Synthesis of Benzalkonium-Templated Mesostructured Silica Antibacterial Agents

Viktor Dubovoy, Anjani Ganti, Tao Zhang, Hassan Al-Tameemi, Juan D. Cerezo, Jeffrey M. Boyd, Teddy Asefa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Novel mesostructured silica microparticles are synthesized, characterized, and investigated as a drug delivery system (DDS) for antimicrobial applications. The materials exhibit a relatively high density (0.56 g per 1 g SiO2) of benzalkonium chloride (BAC), pore channels of 18 Å in width, and a high surface area (1500 m2/g). Comparison of the small-angle X-ray diffraction (SAXRD) pattern with Barrett-Joyner-Halenda (BJH) pore size distribution data suggests that the 18 Å pores exhibit short-range ordering and a wall thickness of ca. 12 Å. Drug release studies demonstrate pH-responsive controlled release of BAC without additional surface modification of the materials. Prolonged drug release data were analyzed using a power law (Korsmeyer-Peppas) model and indicate substantial differences in release mechanism in acidic (pH 4.0, 5.0, 6.5) versus neutral (pH 7.4) solutions. Microbiological assays demonstrate a significant time-dependent reduction in Staphylococcus aureus and Salmonella enterica viability above 10 and 130 mg L-1 of the synthesized materials, respectively. The viability of cells is reduced over time compared to control samples. The findings will help in widening the use of BAC as a disinfectant and bactericidal agent, especially in pharmaceutical and food industries where Gram-positive and Gram-negative bacterial contamination is common.

Original languageEnglish
Pages (from-to)13534-13537
Number of pages4
JournalJournal of the American Chemical Society
Volume140
Issue number42
DOIs
Publication statusPublished - Oct 24 2018

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Benzalkonium Compounds
Bactericides
Hydrothermal synthesis
Silicon Dioxide
Silica
Anti-Bacterial Agents
Pharmaceutical Preparations
Disinfectants
Chloride Channels
Salmonella
Salmonella enterica
Food Industry
Drug Industry
Drug Delivery Systems
X-Ray Diffraction
Drug products
Diffraction patterns
Pore size
Surface treatment
Staphylococcus aureus

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

One-Pot Hydrothermal Synthesis of Benzalkonium-Templated Mesostructured Silica Antibacterial Agents. / Dubovoy, Viktor; Ganti, Anjani; Zhang, Tao; Al-Tameemi, Hassan; Cerezo, Juan D.; Boyd, Jeffrey M.; Asefa, Teddy.

In: Journal of the American Chemical Society, Vol. 140, No. 42, 24.10.2018, p. 13534-13537.

Research output: Contribution to journalArticle

Dubovoy, Viktor ; Ganti, Anjani ; Zhang, Tao ; Al-Tameemi, Hassan ; Cerezo, Juan D. ; Boyd, Jeffrey M. ; Asefa, Teddy. / One-Pot Hydrothermal Synthesis of Benzalkonium-Templated Mesostructured Silica Antibacterial Agents. In: Journal of the American Chemical Society. 2018 ; Vol. 140, No. 42. pp. 13534-13537.
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