One-step multilevel microfabrication by reaction-diffusion

Christopher J. Campbell, Rafal Klajn, Marcin Fialkowski, Bartosz A. Grzybowski

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


A new experimental technique is described that uses reaction-diffusion phenomena as a means of one-step microfabrication of complex, multilevel surface reliefs. Thin films of dry gelatin doped with potassium hexacyanoferrate are chemically micropatterned with a solution of silver nitrate delivered from an agarose stamp. Precipitation reaction between the two salts causes the surface to deform. The mechanism of surface deformation is shown to involve a sequence of reactions, diffusion, and gel swelling/contraction. This mechanism is established experimentally and provides a basis of a theoretical lattice-gas model that allows prediction surface topographies emerging from arbitrary geometries of the stamped features. The usefulness of the technique is demonstrated by using it to rapidly prepare two types of mold for passive microfluidic mixers.

Original languageEnglish
Pages (from-to)418-423
Number of pages6
Issue number1
Publication statusPublished - Jan 4 2005

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Fingerprint Dive into the research topics of 'One-step multilevel microfabrication by reaction-diffusion'. Together they form a unique fingerprint.

Cite this