Abstract
We report here a method to coat orthopedic metals with the artificial bone material organoapatite. The growth of organoapatite on titanium alloy surfaces of foils and porous cylinders involves sequential preadsorption of poly(L-lysine) and poly(L-glutamic acid) on metal, followed by exposure to organoapatite-precipitating solutions. The organoapatite characterization of the coating was carried out by transmission electron microscopy, electron diffraction, scanning electron microscopy, energy-dispersive X-ray scattering, powder X-ray diffraction, FT-IR, and elemental analysis. The preadsorbed poly(amino acids) in the form of a self-assembled bilayer of oppositely charged macromolecules can lead to a surface coverage of titanium alloy in the range of 70-90%. The deposition mechanisms could involve the surface capture of embryonic crystals and the nucleation of apatite on the bilayer. Bioabsorbable organoapatite could serve as a tissue-engineering scaffold for bone regeneration into porous implants.
| Original language | English |
|---|---|
| Pages (from-to) | 504-515 |
| Number of pages | 12 |
| Journal | Journal of Biomedical Materials Research |
| Volume | 47 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1999 |
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Keywords
- Bone tissue engineering
- Coating
- Organoapatite
- Poly(amino acid)
- Titanium
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
Cite this
Organoapatite growth on an orthopedic alloy surface. / Hwang, Julia J.; Jaeger, Kevin; Hancock, James; Stupp, Samuel I.
In: Journal of Biomedical Materials Research, Vol. 47, No. 4, 1999, p. 504-515.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Organoapatite growth on an orthopedic alloy surface
AU - Hwang, Julia J.
AU - Jaeger, Kevin
AU - Hancock, James
AU - Stupp, Samuel I
PY - 1999
Y1 - 1999
N2 - We report here a method to coat orthopedic metals with the artificial bone material organoapatite. The growth of organoapatite on titanium alloy surfaces of foils and porous cylinders involves sequential preadsorption of poly(L-lysine) and poly(L-glutamic acid) on metal, followed by exposure to organoapatite-precipitating solutions. The organoapatite characterization of the coating was carried out by transmission electron microscopy, electron diffraction, scanning electron microscopy, energy-dispersive X-ray scattering, powder X-ray diffraction, FT-IR, and elemental analysis. The preadsorbed poly(amino acids) in the form of a self-assembled bilayer of oppositely charged macromolecules can lead to a surface coverage of titanium alloy in the range of 70-90%. The deposition mechanisms could involve the surface capture of embryonic crystals and the nucleation of apatite on the bilayer. Bioabsorbable organoapatite could serve as a tissue-engineering scaffold for bone regeneration into porous implants.
AB - We report here a method to coat orthopedic metals with the artificial bone material organoapatite. The growth of organoapatite on titanium alloy surfaces of foils and porous cylinders involves sequential preadsorption of poly(L-lysine) and poly(L-glutamic acid) on metal, followed by exposure to organoapatite-precipitating solutions. The organoapatite characterization of the coating was carried out by transmission electron microscopy, electron diffraction, scanning electron microscopy, energy-dispersive X-ray scattering, powder X-ray diffraction, FT-IR, and elemental analysis. The preadsorbed poly(amino acids) in the form of a self-assembled bilayer of oppositely charged macromolecules can lead to a surface coverage of titanium alloy in the range of 70-90%. The deposition mechanisms could involve the surface capture of embryonic crystals and the nucleation of apatite on the bilayer. Bioabsorbable organoapatite could serve as a tissue-engineering scaffold for bone regeneration into porous implants.
KW - Bone tissue engineering
KW - Coating
KW - Organoapatite
KW - Poly(amino acid)
KW - Titanium
UR - http://www.scopus.com/inward/record.url?scp=0031573489&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031573489&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-4636(19991215)47:4<504::AID-JBM6>3.0.CO;2-O
DO - 10.1002/(SICI)1097-4636(19991215)47:4<504::AID-JBM6>3.0.CO;2-O
M3 - Article
C2 - 10497285
AN - SCOPUS:0031573489
VL - 47
SP - 504
EP - 515
JO - Journal of Biomedical Materials Research - Part A
JF - Journal of Biomedical Materials Research - Part A
SN - 0021-9304
IS - 4
ER -