TY - JOUR
T1 - Organoapatite growth on an orthopedic alloy surface
AU - Hwang, Julia J.
AU - Jaeger, Kevin
AU - Hancock, James
AU - Stupp, Samuel I.
PY - 1999
Y1 - 1999
N2 - We report here a method to coat orthopedic metals with the artificial bone material organoapatite. The growth of organoapatite on titanium alloy surfaces of foils and porous cylinders involves sequential preadsorption of poly(L-lysine) and poly(L-glutamic acid) on metal, followed by exposure to organoapatite-precipitating solutions. The organoapatite characterization of the coating was carried out by transmission electron microscopy, electron diffraction, scanning electron microscopy, energy-dispersive X-ray scattering, powder X-ray diffraction, FT-IR, and elemental analysis. The preadsorbed poly(amino acids) in the form of a self-assembled bilayer of oppositely charged macromolecules can lead to a surface coverage of titanium alloy in the range of 70-90%. The deposition mechanisms could involve the surface capture of embryonic crystals and the nucleation of apatite on the bilayer. Bioabsorbable organoapatite could serve as a tissue-engineering scaffold for bone regeneration into porous implants.
AB - We report here a method to coat orthopedic metals with the artificial bone material organoapatite. The growth of organoapatite on titanium alloy surfaces of foils and porous cylinders involves sequential preadsorption of poly(L-lysine) and poly(L-glutamic acid) on metal, followed by exposure to organoapatite-precipitating solutions. The organoapatite characterization of the coating was carried out by transmission electron microscopy, electron diffraction, scanning electron microscopy, energy-dispersive X-ray scattering, powder X-ray diffraction, FT-IR, and elemental analysis. The preadsorbed poly(amino acids) in the form of a self-assembled bilayer of oppositely charged macromolecules can lead to a surface coverage of titanium alloy in the range of 70-90%. The deposition mechanisms could involve the surface capture of embryonic crystals and the nucleation of apatite on the bilayer. Bioabsorbable organoapatite could serve as a tissue-engineering scaffold for bone regeneration into porous implants.
KW - Bone tissue engineering
KW - Coating
KW - Organoapatite
KW - Poly(amino acid)
KW - Titanium
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U2 - 10.1002/(SICI)1097-4636(19991215)47:4<504::AID-JBM6>3.0.CO;2-O
DO - 10.1002/(SICI)1097-4636(19991215)47:4<504::AID-JBM6>3.0.CO;2-O
M3 - Article
C2 - 10497285
AN - SCOPUS:0031573489
VL - 47
SP - 504
EP - 515
JO - Journal of Biomedical Materials Research
JF - Journal of Biomedical Materials Research
SN - 0021-9304
IS - 4
ER -