Organoapatite growth on an orthopedic alloy surface

Julia J. Hwang, Kevin Jaeger, James Hancock, Samuel I Stupp

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We report here a method to coat orthopedic metals with the artificial bone material organoapatite. The growth of organoapatite on titanium alloy surfaces of foils and porous cylinders involves sequential preadsorption of poly(L-lysine) and poly(L-glutamic acid) on metal, followed by exposure to organoapatite-precipitating solutions. The organoapatite characterization of the coating was carried out by transmission electron microscopy, electron diffraction, scanning electron microscopy, energy-dispersive X-ray scattering, powder X-ray diffraction, FT-IR, and elemental analysis. The preadsorbed poly(amino acids) in the form of a self-assembled bilayer of oppositely charged macromolecules can lead to a surface coverage of titanium alloy in the range of 70-90%. The deposition mechanisms could involve the surface capture of embryonic crystals and the nucleation of apatite on the bilayer. Bioabsorbable organoapatite could serve as a tissue-engineering scaffold for bone regeneration into porous implants.

Original languageEnglish
Pages (from-to)504-515
Number of pages12
JournalJournal of Biomedical Materials Research
Volume47
Issue number4
DOIs
Publication statusPublished - 1999

Fingerprint

Orthopedics
Titanium alloys
Bone
Metals
Tissue Scaffolds
Apatites
Apatite
Scaffolds (biology)
X ray scattering
Macromolecules
Tissue engineering
Electron diffraction
X ray powder diffraction
Metal foil
Lysine
Amino acids
Glutamic Acid
Nucleation
Transmission electron microscopy
Amino Acids

Keywords

  • Bone tissue engineering
  • Coating
  • Organoapatite
  • Poly(amino acid)
  • Titanium

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Organoapatite growth on an orthopedic alloy surface. / Hwang, Julia J.; Jaeger, Kevin; Hancock, James; Stupp, Samuel I.

In: Journal of Biomedical Materials Research, Vol. 47, No. 4, 1999, p. 504-515.

Research output: Contribution to journalArticle

Hwang, Julia J. ; Jaeger, Kevin ; Hancock, James ; Stupp, Samuel I. / Organoapatite growth on an orthopedic alloy surface. In: Journal of Biomedical Materials Research. 1999 ; Vol. 47, No. 4. pp. 504-515.
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