Organosilatrane building blocks

Bradley J. Brennan, Devens Gust, Gary W. Brudvig

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Phenylsilatrane analogues containing reactive amino, bromo, boronic ester, and alkynyl functional groups for coupling reactions have been prepared. Pinacol boronic ester and ethynyl analogues were synthesized from 4- bromophenylsilatrane by palladium catalyzed reactions. The silatrane functional group was shown to be stable during the palladium catalysis procedures and silica-gel purification, making the molecules amenable to further synthetic manipulation. The described phenylsilatranes are useful building blocks for forming more complex organosilatrane species.

Original languageEnglish
Pages (from-to)1062-1064
Number of pages3
JournalTetrahedron Letters
Volume55
Issue number5
DOIs
Publication statusPublished - Jan 29 2014

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Keywords

  • Alkyne
  • Amino
  • Boronic ester
  • Cross-coupling
  • Silatrane

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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