Oxidant-free conversion of cyclic amines to lactams and H2 using water as the oxygen atom source

Julia R. Khusnutdinova, Yehoshoa Ben-David, David Milstein

Research output: Contribution to journalArticle

74 Citations (Scopus)


Direct conversion of cyclic amines to lactams utilizing water as the only reagent is catalyzed by pincer complex 2. In contrast to previously known methods of amine-to-amide conversion, this reaction occurs in the absence of oxidants and is accompanied by liberation of H2, with water serving as a source of oxygen atom. Formation of a cyclic hemiaminal intermediate plays a key role in enabling such reactivity. This represents an unprecedented, conceptually new type of amide formation reaction directly from amines and water under oxidant-free conditions.

Original languageEnglish
Pages (from-to)2998-3001
Number of pages4
JournalJournal of the American Chemical Society
Issue number8
Publication statusPublished - Feb 26 2014


ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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