Abstract
Direct conversion of cyclic amines to lactams utilizing water as the only reagent is catalyzed by pincer complex 2. In contrast to previously known methods of amine-to-amide conversion, this reaction occurs in the absence of oxidants and is accompanied by liberation of H2, with water serving as a source of oxygen atom. Formation of a cyclic hemiaminal intermediate plays a key role in enabling such reactivity. This represents an unprecedented, conceptually new type of amide formation reaction directly from amines and water under oxidant-free conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 2998-3001 |
| Number of pages | 4 |
| Journal | Journal of the American Chemical Society |
| Volume | 136 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Feb 26 2014 |
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry
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Khusnutdinova, J. R., Ben-David, Y., & Milstein, D. (2014). Oxidant-free conversion of cyclic amines to lactams and H2 using water as the oxygen atom source. Journal of the American Chemical Society, 136(8), 2998-3001. https://doi.org/10.1021/ja500026m