Oxidative addition of ammonia to form a stable monomeric amido hydride complex

Jing Zhao, Alan S Goldman, John F. Hartwig

Research output: Contribution to journalArticle

289 Citations (Scopus)

Abstract

The insertion of an iridium complex into an N-H bond in ammonia leads to a stable monomeric amido hydride complex in solution at room temperature. This reaction advances the transition-metal coordination chemistry of ammonia beyond its role for more than a century as an ancillary ligand. The precursor for this insertion reaction is an iridium(I) olefin complex with an aliphatic ligand containing one carbon and two phosphorus donor atoms. Kinetic and isotopic labeling studies indicate that olefin dissociates to give a 14-electron iridium(I) fragment, which then reacts with ammonia. This cleavage of the N-H bond under neutral conditions provides a foundation on which to develop future mild catalytic transformations of ammonia, such as olefin hydroamination and arene oxidative amination.

Original languageEnglish
Pages (from-to)1080-1082
Number of pages3
JournalScience
Volume307
Issue number5712
DOIs
Publication statusPublished - Feb 18 2005

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Ammonia
Iridium
Alkenes
Ligands
Amination
Phosphorus
Carbon
Metals
Electrons
Temperature

ASJC Scopus subject areas

  • General

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Oxidative addition of ammonia to form a stable monomeric amido hydride complex. / Zhao, Jing; Goldman, Alan S; Hartwig, John F.

In: Science, Vol. 307, No. 5712, 18.02.2005, p. 1080-1082.

Research output: Contribution to journalArticle

Zhao, Jing ; Goldman, Alan S ; Hartwig, John F. / Oxidative addition of ammonia to form a stable monomeric amido hydride complex. In: Science. 2005 ; Vol. 307, No. 5712. pp. 1080-1082.
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